The Integrator subunits function in hematopoiesis.

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Jon Moulton
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The Integrator subunits function in hematopoiesis.

Tao S, Cai Y, Sampath K.  The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling.  Development. 2009 Jul 15. [Epub ahead of print]
 
Abstract excerpt: "Integrator complex proteins are known to directly interact with RNA polymerase II to mediate 3' end processing of U1 and U2 snRNAs. We have identified several subunits of the Integrator complex in zebrafish. Antisense morpholino-mediated knockdown of the Integrator subunit 5 (Ints5) in zebrafish embryos affects U1 and U2 snRNA processing, leading to aberrant splicing of smad1 and smad5 RNA, and reduced expression of the hematopoietic genes stem cell leukemia (scl, also known as tal1) and gata1."
http://www.ncbi.nlm.nih.gov/pubmed/19605500