Transalation of IC50 values from whole blood assays to with cellular assays

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srinuh2000
srinuh2000's picture
Transalation of IC50 values from whole blood assays to with cellular assays

Dear Sir
I am working in Drug discovery Company, I have one question
Whenever we screen any molecule for activity, IC 50 value will change from whole blood, PBMC and PMNL (Whole blood to cellular assay)
Why this change is happening? What percentage of IC50 goes up or down from whole blood to cellular systems

usavel
usavel's picture
You can ref to this  for

You can ref to this  for further understanding.
Toxicology and Applied Pharmacology, Vol. 148, No. 1, pages 46-49, 1998
21 References, 1998