In Vivo& in Vitro Analysis of Molecular Mechanism of Chromosome Segregation

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Amar Annamalai
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In Vivo& in Vitro Analysis of Molecular Mechanism of Chromosome Segregation

 Postdoctoral position in Center for Molecular Biology, University of Heidelberg , Germany

Job Description

Applications are invited for the postdoctoral position.

The mitotic spindle is a dynamic machine that segregate the replicated chromosomes between the two daughter cells during cell division. In anaphase a shrinking kinetochore microtubules move the chromosomes towards the spindle poles. Concurrently, the spindle midzone is formed in the centre of the spindle by overlapping microtubules where microtubule-bundling proteins (Ase1), kinesin motor proteins (Cin8 and Kip1), chromosomal passenger proteins (separase-Slk19), +TIPs (Bim1/EB1, Stu1/CLASP, Bik1/CLIP-170, Stu2/XMAP215) and signaling molecules (Aurora B kinase) localize 1-5. The spindle midzone stabilizes the anaphase spindle in all eukaryotic cells by crosslinking microtubules of the two half spindles It also drives spindle elongation in anaphase B and regulates cleavage furrow formation during cytokinesis in animal cells. The aim of this project is to study the biochemical properties of spindle midzone proteins using TIRF microscopy assays. Findings will be verified in the cell system using cell and molecular biology methods.

Conditions We are looking for a highly motivated scientist with a strong background in biochemistry, cell biology or molecular biology. The successful candidate will be part of an international, highly motivated team of PhD students and postdocs that works at the forefront of scientific research. Sonstiges: Miscellaneous:

Please send written applications (CV, letter of motivation, transcripts) with 2-3 names of references to Prof. Dr. Elmar Schiebel, ZMBH, University of Heidelberg, INF 282, 69120 Heidelberg, Germany (

Application to: 13-08-2010

Im Neuenheimer Feld 282 69120 Heidelberg

(06221) 546800

(06221) 546809


Agency website:

Faculty / Institution:
Ruprecht-Karls-Universität Heidelberg

The University of Heidelberg is aiming for increasing the share of women in the fields of one in which they are underrepresented in the past. Suitably qualified women are asked for their application.

Handicapped applicants will be suitability for the same set of priority.

Further Fellowship Information and Application$.startup%3FMODUL%3DLS%26M1%3D1%26M2%3D0%26M3%3D0%26PRO%3D8474&sl=de&tl=en