Postdoctoral Positions In Synthetic Biology : Nottingham, United Kingdom

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Postdoctoral Positions In Synthetic Biology : Nottingham, United Kingdom

Three Postdoctoral Positions In Synthetic Biology
Postdoctoral applications are invited to three highly ambitious linked synthetic biology projects at the University of Nottingham, UK. The three researchers will be based at the state-of-the-art Centre for Biomolecular Sciences (CBS) and will also be members of the Interdisciplinary Computing and Complex Systems (ICOS) research group. Each candidate will be allocated to one of three Synthetic Biology (SB) projects: AUDACIOUS, CADMAD or ROADBLOCK. These projects, funded by the UK EPSRC and the EU FP7, are led by Profs. Natalio Krasnogor, Miguel Cámara and Dr. Stephan Heeb.
ROADBLOCK objective is the design of living intelligent surfaces that can be used to sense and effectively treat bacterial infections. The postdoctoral fellow will focus on SB strategies to create designer bacteria consortia that could act as reliable and self-repairing bio-programmable shields against colonisation. ROADBLOCK constructs will also be applicable to other clinical, environmental or industrial scenarios in which bacterial colonisation and biofilm formation should be avoided or tightly controlled.
While ROADBLOCK is an applied SB venture, AUDACIOUS is a fundamental science SB project. Notwithstanding SB’s recent advances in biological part construction and protocol standardisation, SB in vivo devices remain of very small “logical” complexity due to several detrimental factors affecting in vivo programmability. The postdoctoral candidate working on AUDACIOUS will thus seek to investigate ways in which fundamental breakthroughs could be achieved to ratchet up the complexity of in vivo logic circuitries and the way these communicate with the external world (e.g. via standard electronics, microfluidics, optogenetics, etc).
At the interface between ROADBLOCK and AUDACIOUS, the postdoctoral researcher embedded in CADMAD will have access to a new experimental technology for the high throughput synthesis of combinatorial DNA libraries and will help drive the development of this technology and its application to both ROADBLOCK and AUDACIOUS, with a particular emphasis on combinatorial design of genetic networks and on self-assembled DNA/RNA nanostructures.
These projects include collaborators across the UK, USA, Israel, France, Germany, Denmark, Switzerland and Spain.
Candidates must have outstanding BSc & PhD track records in (ideally) synthetic biology or molecular microbiology, substantial wet lab experience, be very familiar with bacterial cloning, construction and use of recombinant genes, techniques for DNA self-assembly/origami and confocal microscopy, be able to work both independently and as part of a multidisciplinary team, have published in high quality journals, be highly ambitious, driven and willing to travel to our partner institutions around the globe. Experience in biofilm formation and analysis techniques as well as the use of scanning electron microscopy and atomic force microscopy will be an advantage.
Informal enquiries may be addressed to Prof. N. Krasnogor ( while further information, including, application procedures are detailed at
These vacancies will close on the 24 July 2012 or when outstanding candidates are identified, even if this takes place before the closing date.

Deadline: 24 July 2012

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