Postdoctoral position

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Amar Annamalai
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Postdoctoral position

Job Description

Reference: POSTDOC29
Location: Waltham, MA, USA
Salary: Competitive + excellent benefits ($k - $k for search optimization only)

The next generation of medicines.
How will you take them even further?

At AstraZeneca, we’re constantly striving to make new discoveries. Discoveries that will make a meaningful difference to health globally. We already have an exceptional product pipeline, and everyone here has a part to play in making sure that pipeline fulfills its potential. This is your opportunity to join them – and to fulfill your own.

We have an exciting opportunity for a synthetic organic chemist to join our Infection Innovative Medicines department where you’ll plan and execute novel synthetic methodology towards the assembly of unusual molecules of biological interest. The research will explore the substrate scope to investigate a variety of paths towards inducing an internal redox reaction that leads to heterocycles of unusual architecture. You’ll also delineate mechanistic details and a transition state model for the redox reaction and expand on the types of compounds that could be made. This research will contribute to the construction of compounds envisioned to expand the AstraZeneca compound collection for biological testing.

You’ll focus on the design of novel chemotypes for reactivity, the synthesis of target compounds and the monitoring of reaction kinetics while working with an academic advisor and scientists across other disciplines. We’ll expect you to deliver the results of your novel research in-house, our academic partner’s research group, Infection department leaders, global working groups and externally through meetings and publications.

Your major responsibilities
• Develop novel methodologies to expand the scope and structural motifs of the internal redox chemistry
• Develop a series of synthetic constructs and an efficient platform to measure reaction kinetics and probe reaction transition states
• Show strong initiative in developing ideas and bringing them to functional use within AstraZeneca
• Interface with scientists from across many disciplines while at the same time being able to work independently
• Communicate results both within AstraZeneca via global working groups and externally at meetings and through publications
• Work collaboratively with other experts within Computational Chemistry and Medicinal Chemistry
• Publish scientific papers describing the discovery of novel reactions, novel structures and mechanistic insights include the development of techniques to monitor results

Minimum experience
A PhD in one of the following areas:
• Organic synthesis with expertise in method development and execution of complex multi-step reaction sequences

Preferred experience/requirements
• Demonstrated success across a broad range of synthetic challenges
• Strong working knowledge of physical chemistry principles and applications to synthetic problem solving
• Demonstrated understanding of mechanistic organic chemistry and reaction kinetics
• Understanding of modern computational approaches for transition state simulation and their applications to modern organic chemistry

AstraZeneca – Health Connects Us All

As one of the world's leading pharmaceutical companies, our business is focused on providing innovative, effective medicines that make a real difference in important areas of healthcare. What’s more, we support and encourage our people in discovering their own potential. Excellent learning and development opportunities will be available to you throughout your career here.

AstraZeneca welcomes applications from all sections of the community.
 
 
Contact:     
AstraZeneca Pharmaceuticals LP
Waltham, MA
United States

Job Description
Reference: POSTDOC29
Location: Waltham, MA, USA
Salary: Competitive + excellent benefits ($k - $k for search optimization only)

The next generation of medicines.
How will you take them even further?

At AstraZeneca, we’re constantly striving to make new discoveries. Discoveries that will make a meaningful difference to health globally. We already have an exceptional product pipeline, and everyone here has a part to play in making sure that pipeline fulfills its potential. This is your opportunity to join them – and to fulfill your own.

We have an exciting opportunity for a synthetic organic chemist to join our Infection Innovative Medicines department where you’ll plan and execute novel synthetic methodology towards the assembly of unusual molecules of biological interest. The research will explore the substrate scope to investigate a variety of paths towards inducing an internal redox reaction that leads to heterocycles of unusual architecture. You’ll also delineate mechanistic details and a transition state model for the redox reaction and expand on the types of compounds that could be made. This research will contribute to the construction of compounds envisioned to expand the AstraZeneca compound collection for biological testing.

You’ll focus on the design of novel chemotypes for reactivity, the synthesis of target compounds and the monitoring of reaction kinetics while working with an academic advisor and scientists across other disciplines. We’ll expect you to deliver the results of your novel research in-house, our academic partner’s research group, Infection department leaders, global working groups and externally through meetings and publications.

Your major responsibilities
• Develop novel methodologies to expand the scope and structural motifs of the internal redox chemistry
• Develop a series of synthetic constructs and an efficient platform to measure reaction kinetics and probe reaction transition states
• Show strong initiative in developing ideas and bringing them to functional use within AstraZeneca
• Interface with scientists from across many disciplines while at the same time being able to work independently
• Communicate results both within AstraZeneca via global working groups and externally at meetings and through publications
• Work collaboratively with other experts within Computational Chemistry and Medicinal Chemistry
• Publish scientific papers describing the discovery of novel reactions, novel structures and mechanistic insights include the development of techniques to monitor results

Minimum experience
A PhD in one of the following areas:
• Organic synthesis with expertise in method development and execution of complex multi-step reaction sequences

Preferred experience/requirements
• Demonstrated success across a broad range of synthetic challenges
• Strong working knowledge of physical chemistry principles and applications to synthetic problem solving
• Demonstrated understanding of mechanistic organic chemistry and reaction kinetics
• Understanding of modern computational approaches for transition state simulation and their applications to modern organic chemistry

AstraZeneca – Health Connects Us All

As one of the world's leading pharmaceutical companies, our business is focused on providing innovative, effective medicines that make a real difference in important areas of healthcare. What’s more, we support and encourage our people in discovering their own potential. Excellent learning and development opportunities will be available to you throughout your career here.

AstraZeneca welcomes applications from all sections of the community.
 
 
Contact:     
AstraZeneca Pharmaceuticals LP
Waltham, MA
United States

Deadline: April 29th 2013

For more details