Postdoctoral Fellow at the Molecular Cell Biology Group at Switzerland

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test1242
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Postdoctoral Fellow at the Molecular Cell Biology Group at Switzerland

The Paul Scherrer Institute is with 1400 employees the largest research centre for the natural and engineering sciences in Switzerland and a worldwide leading user laboratory. Its research activities are concentrated on the main topics structure of matter, energy and environmental research as well as human health.
 
The Molecular Cell Biology Group at the Laboratory of Biomolecular Research at PSI studies the biology of vascular endothelial growth factors, VEGFs, and their receptors in vessel development and homeostasis. Our focus is on structural aspects of receptor signaling using X-ray crystallography, single particle electron microscopy, and small angle solution scattering (SAXS). Excellent infrastructure for these techniques are available at the synchrotron light source (SLS) and at our in-house facilities at the Laboratory of Biomolecular Research. For our project ‘structural and functional analysis of VEGF receptor/ ligand complexes by single particle electron microscopy and X-ray crystallography’ we are looking for a Postdoctoral Fellow at the Molecular Cell Biology Group
 
Your tasks
 
• Production of proteins in insect and mammalian cells, protein purification and isolation of receptor/ligand complexes
 
• Biophysical characterization of protein complexes
 
• Structural analysis of protein complexes primarily by single particle electron microscopy to obtain a general view of receptor structure
 
• Refinement of structures by X-ray crystallography applied to individual protein domains
 
• Complementary functional analysis of receptor complexes in endothelial cells
 
Your profile
 
The successful candidate should have a background in either biology, biochemistry, biophysics, or biotechnology. Particular in protein engineering and production, purification, and characterization, or in structural analysis of biomolecules using either single particle electron microscopy or X-ray crystallography.
 
The candidate will work in the Molecular Cell Biology Group at the Laboratory of Biomolecular Research and at the synchrotron light source (SLS) at PSI.
 
For further information please contact: Prof. Dr Kurt Ballmer-Hofer, phone +41 56 310 41 65, eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%6b%75%72%74%2e%62%61%6c%6c%6d%65%72%40%70%73%69%2e%63%68%22%3e%6b%75%72%74%2e%62%61%6c%6c%6d%65%72%40%70%73%69%2e%63%68%3c%2f%61%3e%27%29%3b'))
 
Please submit your application (including CV, list of publications, statement of research interests and addresses of at least three referees) quoting the index number 2312 by e-mail to eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%68%65%64%77%69%67%2e%68%61%62%65%72%73%61%61%74%40%70%73%69%2e%63%68%22%3e%68%65%64%77%69%67%2e%68%61%62%65%72%73%61%61%74%40%70%73%69%2e%63%68%3c%2f%61%3e%27%29%3b')) or to Paul Scherrer Institut, Human Resources, index number 2312, Hedwig Habersaat, 5232 Villigen PSI, Switzerland.
 
For Further information