We are actively seeking an individual who can join our recently opened laboratory as a postdoctoral research assistant in the Montreal Neurological Institute at McGill University.? Our research activities are aimed at determining common and core cellular biological pathways that are relevant to major neurodegenerative disorders. To this end, we have been using genetic model organisms as an approach to dissect the pathogenesis of neurodegenerative disease. Our research program, which involves a combination analysis of flies and mice, has proven to be a valuable approach to understanding the pathology of neurodegeneration. (Refs: Tsuda et al. (2005), Cell 122:633-644; Tsuda et al. (2008), Cell 133:963-977). The position available involves a project designed to provide a better understanding of the molecular pathology of ALS, commonly known as Lou Gehrig’s disease, with our newly created mice model.
This full time appointment is available immediately. The candidate should hold a Ph.D, obtained no more than 2 years ago, or be expected to graduate with a Ph.D. in 2013. Extensive knowledge and practice in mice genetics, immunohistochemistry and confocal microscopy are required. The candidate also needs to be familiar with techniques in molecular biology and protein chemistry. The most competitive candidates will be those with at least one first-author publication in the standard journals, and should be committed to eventually becoming self-funded with fellowships.
Candidates should provide a CV outlining research productivity, pdfs of relevant publications, and the names of two individuals who would be willing to provide a letter of recommendation (with their contact information). Inquiries and applications should be directed to Dr. Hiroshi Tsuda at firstname.lastname@example.org. The deadline to submit applications is February 28, 2012.
The Montreal Neurological Institute is a unique academic medical center which provides both state-of-the-art research facilities and exceptional clinical care for neurodegenerative disease (http://www.mni.mcgill.ca /frontpage/). McGill University is situated in the very heart of Montréal, Canada, a vibrant multi-cultural city and the metropolis of Québec. McGill University has a rich history of achievements in neuroscience and is ranked as one of the top 20 universities in the world. For full details about conducting postdoctoral studies at McGill, go to www.mcgill.ca/gps/postdocs.
Han, S.M., Tsuda, H., Yang, Y., Vibbert,J., Tong, C., Cottee, P, Haueter, C., Prasain, J., Bellen, H.J., Miller, M.A. (2012). Secreted VAPB/ALS8 Major Sperm?Protein Domains Modulate Mitochondrial Localization and Morphology via Growth Cone Guidance Receptors. Developmental Cell, Feb 14;22(2):348-62.
Mitne-Neto M., Machado-Costac M., Marchetto M.C., Bengtson M.H., Joazeiro C.A., Tsuda H., Hugo J. Bellenf, Helga A. C., Silva H.C. , Oliveira A.S., Muotri A. R., Zatz M.(2011). Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem-cells of ALS8 patients. Molecular?Human Genetics, Sep 15;20(18):3642-52.
Tsuda, H., Han, S.M., Yang, Y., Tong, C., Lin, Y.Q., Mohan, K., Haueter, C., Zoghbi, A., Harati, Y., Kwan, J., Miller, M.A., Bellen, H.J. (2008). The?Amyotrophic Lateral Sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell, Jun 13, 133:963-977.
Tsuda, H., Jafar-Nejad, H., Patel, A.J., Sun, Y., Chen, H.K., Rose, M.F., Venken, K.J., Botas, J., Orr, H.T., Bellen, H.J., Zoghbi, H.Y. (2005). The AXH?domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell, Aug 26; 122:633-644.
Deadline: February 20, 2013