Post-Doctoral position in Marie Curie funded TRANSPATH Project

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Post-Doctoral position in Marie Curie funded TRANSPATH Project

Job Title:      Post-Doctoral position in Marie Curie funded TRANSPATH Project : Transglutaminase in disease: a novel therapeutic target.

Application Deadline:     6/15/2012

Job Description
A postdoctoral fellowship is available for 2 years within the framework of the Marie Curie Integrated Training network TRANSPATH Transglutaminase in disease: a novel therapeutic target (Project no.: 289964). Please refer to for further information.

The successful candidate will be employed by the spin out SME partner X-LINK and will be mainly based in the laboratories associated with School of Life & Health Sciences, Aston University, Birmingham, UK. The TRANSPATH network involves 10 other Partners and two Associate industrial Partners across Europe. The successful candidate will be involved with other members of the network, and be expected to attend network courses, meetings and workshops.

The aim of this post is the synthesis of irreversible inhibitors specific to TG2 based on existing lead compounds with the aid of in silico structure based computational methods. Transglutaminases are a family of protein crosslinking enzymes which have a number of physiological functions but which are involved in a variety pathophysiological diseases including celiac disease, neurodegeneration and cancer. See Structure and regulation of type 2 transglutaminase in relation to its physiological functions and pathological roles (2010) Bergamini CM, Collighan R, Wang Z, Griffin M. Adv. Enzymology. 78: 1-46 ; Synthesis of potent water soluble tissue transglutaminase inhibitors (2008) M. Griffin, A. Mongeot, R. Collighan, R.E. Saint, R.A. Jones, I.G.C. Coutts and D.L. Rathbone Bioorg. Med. Chem. Lett. 18: 5559–5562.

Inhibitors specific to individual transglutaminases will be designed based on results obtained with previously developed inhibitors and suitable compounds will be taken forward for synthesis and testing by partners in cell and experimental models of disease.

To be considered for the position it is required that you have preferably completed a PhD in synthetic organic chemistry and have some experience of molecular modelling. You will also need to meet the eligibility criteria of the Marie Curie Actions: (1) you have more than 4 years research experience but not more than 5 after the degree which allowed entry into a PhD programme (normally a Masters degree) and/or a PhD and (2) you have not been working/studying in the UK for more than 12 of the last 36 months. Preference will be given to applicants who are citizens or residents of the European Union and associated countries.

Applicants must include in their application:
• A letter of application including a description of the underlying motivation to apply for this position
• CV, including a description of education, former positions, teaching and administrative experience.
• Education certificates. If your education is not structured as a bachelor/master, please inform which courses correspond to bachelor- and master-level.
• A publication list.
• The names and email addresses of two or three referees.

All the above should be sent to Professor Martin Griffin ( or Dr Dan Rathbone ( School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
The closing date for applications is 15th June 2012.

For further information, see the Marie Curie Integrated Training Network (ITN) web page or contact Professor Martin Griffin, telephone +44 (0) 121 204 3943, email: eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%4d%2e%47%72%69%66%66%69%6e%40%61%73%74%6f%6e%2e%61%63%2e%75%6b%22%3e%4d%2e%47%72%69%66%66%69%6e%40%61%73%74%6f%6e%2e%61%63%2e%75%6b%3c%2f%61%3e%27%29%3b'))

The salary for this post is set by the regulations governing Marie Curie/FP7 projects. Please download and read the Guide from the Marie Curie Integrated Training Network website for detailed information on salary (
For information, the gross salary of approximately €5,850 per month will be paid in GBP equivalent. In addition, the successful applicant will receive a monthly mobility allowance in the UK to an approximate value of €840 (single) and €1203 (married/family) paid in GBP. In all cases this total income will be assessed for UK tax (National Insurance and PAYE) for both the company contribution and personal tax before receiving the net amount. Further details will be available on request.

Contract Type: Temporary - 24 month’s duration.

Position: Experienced Researcher 4 years of research experience after Masters but no more than 5 and/or PhD.

Contact Persons:
Prof M Griffin, Aston University, Birmingham; eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%6d%2e%67%72%69%66%66%69%6e%40%61%73%74%6f%6e%2e%61%63%2e%75%6b%22%3e%6d%2e%67%72%69%66%66%69%6e%40%61%73%74%6f%6e%2e%61%63%2e%75%6b%3c%2f%61%3e%27%29%3b'))
Dr Neil Barnes, X-Link Limited, Biocity, Nottingham; eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%6e%62%2e%78%6c%69%6e%6b%40%67%6d%61%69%6c%2e%63%6f%6d%22%3e%6e%62%2e%78%6c%69%6e%6b%40%67%6d%61%69%6c%2e%63%6f%6d%3c%2f%61%3e%27%29%3b'))
Contact:      Professor Martin Griffin
Aston University
Aston Triangle
Birmingham,  B4 7ET
United Kingdom


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