Opening For Postdoctoral Scientist - London

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Amar Annamalai
Amar Annamalai's picture
Opening For Postdoctoral Scientist - London

 About the Role: You should be interested in understanding the molecular basis of the host immune response to different strains of Mycobacterium tuberculosis and show interest in the research recently published by Anne O’Garra’s group in Nature 2010 regarding potential factors underlying the pathogenesis of tuberculosis. The project will be to test potential pathways/targets identified in the blood transcriptome of human tuberculosis, starting with Type I IFN-inducible genes, such including Tripartite motif-containing proteins (TRIMs), by their elimination or perturbation in mouse models of tuberculosis and other bacterial infections for their role in protection or pathogenesis. In addition, the project will require to define molecular mechanisms underlying such pathways affecting tuberculosis protection/pathogenesis and that of other bacterial infections, and during co-infection, initiating with Type I IFN and Type I IFN-inducible genes, such as TRIMs, in macrophages, dendritic cells, inflammatory monocytes and neutrophils where the pathways have been deleted or perturbed. This will be studied in the context of infection with different strains of M. tuberculosis and other bacterial infections, in both mouse and human cells, but also with Pathogen-Associated Molecular Patterns (PAMPs) so as to delineate molecular mechanisms underlying this using a variety of molecular and biochemical methods as pathways of defence or pathogenesis.
To Join us you will need;
A PhD (or in final stages of completion) in molecular immunology
Experience in Molecular immunology,  mechanisms of signal transduction and transcriptional regulation, preferably in innate cells and in vivo mouse work
Knowledge of the regulation of protection or pathogenesis in infection and experience of working in mouse models
An excellent knowledge of the literature of downstream pathways regulating innate immune responses in innate cells
Informal enquires can be made to: Dr Anne O’Garra; email: eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%61%6f%67%61%72%72%61%40%6e%69%6d%72%2e%6d%72%63%2e%61%63%2e%75%6b%22%3e%61%6f%67%61%72%72%61%40%6e%69%6d%72%2e%6d%72%63%2e%61%63%2e%75%6b%3c%2f%61%3e%27%29%3b'))
Lab webpage:
Applications are handled by the UK Shared Business Services; candidates with a solid track record of academic achievements are encouraged to apply. Please visit our job board at and upload your CV along with a letter of motivation, (when saving your documents quote reference IRC155473 in the filename).  If you would like to receive this advert in an alternative format (e.g. large print, Braille, audio or hard copy), or who are unable to apply online should contact us by telephone on 01793 867000 and quote IRC155473.