Job Ref: 81993
Applications are invited for 3-year Postdoctoral Fellowships within the Genomics of Inflammation and Immunity group at the Wellcome Trust Sanger Institute, headed by Dr. Carl Anderson. The group is focused on understanding how genetic variation correlates with susceptibility to immune-mediated diseases and response to pathogenic challenge.
Genome-wide association studies have identified hundreds of common loci associated with immune-mediated disease, though the causal variants at the majority of these loci remain unknown. Furthermore, the role of rare genetic variants in complex disease is poorly defined, largely because powerful association studies for such variants are likely to require tens of thousands of whole-genome sequenced cases and controls. By combining cutting-edge genetic datasets with functional genomic data from a number of relevant primary cell types, the successful fellows will lead research projects to a) better identify coding and non-coding causal variants across a number of complex or Mendelian-like forms of immune-mediated disease or b) identify vaccine response eQTLs and the effect these have on adaptive immunity and vaccine failure.
To achieve these research goals, Fellows will have access to a number of cutting-edge genomic datasets, including:
Genome-wide genetic data from around 30,000 individuals with an immune-mediated disease (including low-coverage whole genome sequences of 5,000 inflammatory bowel disease (IBD) cases) and more than 50,000 population controls.
High-coverage whole-genome sequences from over 1000 individuals with severe primary immune deficiencies.
Functional genomic data (RNA-seq and ATAC-seq) from many relevant cell populations (T cells, macrophages, monocytes etc.) ascertained from controls and individuals with immune-mediated diseases.
Genetic and genomic data from longitudinal studies of vaccine response in individuals undergoing a standard vaccination programme.
Furthermore, fellows are encouraged to propose new projects enabled by the group's extensive network of clinical and scientific collaborators and Sanger's world-class genomic pipelines.
We are looking for individuals who enjoy scientific problem solving, have experience analyzing large-scale genetic and genomic datasets, work effectively in a multi-disciplinary environment and have a relevant PhD. A strong publication record and an interest in the immune system and its diseases would be an advantage.
Motivation and ambition to make a personal contribution to genomic research
A PhD on a relevant subject
Experience with large scale computational analysis
Statistical knowledge and analytical mind-set
Experience with computer programming & scripting
Ability to work with others in a collegiate environment.
Statistical/computational genetics skills and experience
Previous experience with analysis of genome-wide genotyping or sequencing data
Strong scientific publication record
Experience and/or interest in understanding variation in immune response
Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus Bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.
Please provide a CV and cover letter