Life Sciences Postdoctoral Fellow (AZH1203.12)

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Life Sciences Postdoctoral Fellow (AZH1203.12)

Job Description
Life Sciences Postdoctoral Fellow

The mission of the Palo Alto Institute for Research and Education, Inc. (PAIRE) is to facilitate research and education activities conducted at the VA Palo Alto Health Care System (VAPAHCS). The range of research activities is broad and includes special emphasis on biomedical, health services, rehabilitation engineering, mental health and geriatric research endeavors. We also support various educational instruction or other learning experiences of benefit to employees and veterans.

PAIRE, a nonprofit foundation affiliated with the Veterans Affairs Palo Alto Health Care System (VAPAHCS), is seeking a post-doctoral fellow to participate in two related projects involving lipid metabolism in steroid producing cells.
The ideal candidate will possess a Ph.D. in Life Sciences, Molecular Biology or Cell Biology

This is a full-time, regular, exempt position.


Isolate and culture rat/mouse ovarian (granulosa and luteal), testicular (Leydig), and adrenal (andrenocortical) cells and utilize them to examine the effects of hormonal treatment, aging and excessive oxidative stress on SR-BI-mediated selective HDL-cholesteryl ester (CE) uptake, intracellular cholesterol processing and synthesis and secretion of steroid hormones.
Isolate and culture of adrenal, ovary (granulosa and luteal) and testicular (Leydig) cells from mice over expressing (transgenic) or gene ablated for one of the major antioxidant enzymes and utilize them to assess the changes in SR-BI-mediated selective HDL-CE uptake, intracellular cholesterol processing and steroidogenesis.
Isolate and culture rat/mouse ovarian (granulosa and luteal), testicular (Leydig), and adrenal (andrenocortical) cells from NHERF1 or NHERF2 knockout mice or SAMR1 and SAMP8 aging mice and utilize them for studies involving cholesterol transport and steroid hormone synthesis.
Create and/or study the cholesterol transport and steroidogenic functions of designer cell lines over expressing the pairs of antioxidant enzymes, scaffold proteins NHERF1 or NHERF2, SR-BI, SR-BII or CD36.
Carry out real-time quative RT-PCR, western blotting, molecular biology techniques and other biochemical measurements related to Lipidomics and Proteomics.
Perform gene cloning, mutagenesis and functional expression in bacteria and mammalian cells.
Prepare reports, data analysis and scientific papers for presentation and publication
Carry out research assignments with a minimal supervision.
Assist in general laboratory maintenance;
Comply with the local, state and federal safety rules and regulations.


Ph.D. in Life Sciences, Molecular Biology, Cell Biology or related field.
Familiarity with standard cell, molecular and biochemical techniques.
Experience with mammalian cell culture, small animal experimentation.
Basic statistical and computer skills.
Knowledge of lab safety rules and procedures.
Good communication skills and the ability to work cooperatively with other lab members.
Knowledge of safe handling and storage of biohazard chemicals, including radioactive materials.

All PAIRE positions require the completion of a background check.

Environmental Conditions / Physical Demands
Regular exposure to a lab environment
Potential exposure to blood borne pathogens
Exposure to radiation
Exposure to toxic or caustic chemicals or reagents

To Apply:

To be considered for this position you must apply via the PAIRE website,, and include a cover letter addressed to “Hiring Manager,” your resume and 3 professional references.

PAIRE is pleased to be an Equal Opportunity Employer. If you are interested in applying for employment with PAIRE and need special assistance or an accommodation to apply for a posted position, contact our Human Resources department at eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%68%72%40%70%61%69%72%65%2e%6f%72%67%22%3e%68%72%40%70%61%69%72%65%2e%6f%72%67%3c%2f%61%3e%27%29%3b')).

PAIRE is pleased to be an Equal Opportunity Employer.
Palo Alto, CA
United States

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