Complement regulatory molecules

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Amar Annamalai
Amar Annamalai's picture
Complement regulatory molecules

Can anyone tell me a chemical compound acting as complement regulator?

Fraser Moss
Fraser Moss's picture


Here are some papers about humanized or the humanization of cobra venom factor that depletes plasma of essential complement components

1: Fritzinger DC, Hew BE, Thorne M, Pangburn MK, Janssen BJ, Gros P, Vogel CW.
Functional characterization of human C3/cobra venom factor hybrid proteins for
therapeutic complement depletion.
Dev Comp Immunol. 2008 Aug 27. [Epub ahead of print]
PMID: 18760301 [PubMed - as supplied by publisher]

2: Vogel CW, Fritzinger DC.
Humanized cobra venom factor: experimental therapeutics for targeted complement
activation and complement depletion.
Curr Pharm Des. 2007;13(28):2916-26. Review.
PMID: 17979736 [PubMed - indexed for MEDLINE]

3: Brook E, Herbert AP, Jenkins HT, Soares DC, Barlow PN.
Opportunities for new therapies based on the natural regulators of complement
Ann N Y Acad Sci. 2005 Nov;1056:176-88. Review.
PMID: 16387686 [PubMed - indexed for MEDLINE]

4: Vogel CW, Fritzinger DC, Hew BE, Thorne M, Bammert H.
Recombinant cobra venom factor.
Mol Immunol. 2004 Jun;41(2-3):191-9. Review.
PMID: 15159065 [PubMed - indexed for MEDLINE]

5: Kock MA, Hew BE, Bammert H, Fritzinger DC, Vogel CW.
Structure and function of recombinant cobra venom factor.
J Biol Chem. 2004 Jul 16;279(29):30836-43. Epub 2004 May 5.
PMID: 15131128 [PubMed - indexed for MEDLINE]

6: Schlag G, Redl HR, Till GO, Davies J, Martin U, Dumont L.
Anti-L-selectin antibody treatment of hemorrhagic-traumatic shock in baboons.
Crit Care Med. 1999 Sep;27(9):1900-7.
PMID: 10507616 [PubMed - indexed for MEDLINE]

Amar Annamalai
Amar Annamalai's picture
Thank you very much

Thank you very much