Research Associate (3 Posts) 'Genome editing for the analysis of osteoarthritis risk alleles' : Newcastle upon Tyne, United Kingdom
You will join an exciting programme directed toward the functional characterization of osteoarthritis (OA) susceptibility loci, combined with the use of CRISPR/Cas9 genome editing to remove risk alleles from relevant cell lines and from primary cells of OA patients. This strategy will enable candidates to assess which risk alleles are particularly relevant to abnormal tissue function in the OA disease process and which can then be manipulated to create a more disease resistant tissue.
You will hold a PhD in the area of genetics, biochemistry, cell or molecular biology. Expertise in several of the following: molecular biology, cell/tissue culture, gene expression analysis including (real-time) RT-PCR, analysis of cell signalling, electrophoretic mobility shift assays, luciferase reporter assays, western analysis, ChIP, RNAi, overexpression using lentiviral vectors is essential. You must have published work in peer-reviewed journals and have presented work at scientific meetings.
You will have excellent team-working, time-management and organizational skills and able to work to agreed deadlines.
There are three Research posts available, two posts are for five years and one post is for three years.
Informal enquiries may be made to Professor John Loughlin, email: firstname.lastname@example.org or telephone: 0191 208 7178
- Newcastle University
- Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, North East England, United Kingdom
- about 3 hours ago
- March 26, 2015
- Job type
- Research Associate
- $40,000 +
- Postgraduate - Doctorate/PhD
- Employment type
- Job hours