Therapeutic antagonists of miRNAs deplete leukemia-initiating cell activity

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Jon Moulton
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Therapeutic antagonists of miRNAs deplete leukemia-initiating cell activity

Velu CS, Chaubey A, Phelan JD, Horman SR, Wunderlich M, Guzman ML, Jegga AG, Zeleznik-Le NJ, Chen J, Mulloy JC, Cancelas JA, Jordan CT, Aronow BJ, Marcucci G, Bhat B, Gebelein B, Grimes HL. Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity. J Clin Invest. 2014 Jan 2;124(1):222-36. doi: 10.1172/JCI66005. Epub 2013 Dec 16.

http://www.jci.org/articles/view/66005

Knockdown of miRNA by Vivo-Morpholinos in culture: See Supplemental Data page 12. Silencing of miR-21 was essentiallly complete.