Actually, in mice deficient in GLUT-2 HYPERGLYCEMIA is the phenotype not hypoglycemia. As to the cause, the animals are unable to take up glucose in the liver because GLUT-2 is the major glucose receptor on hepatocytes.
References -
Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2
hi jubendradass
Check the following article.
doi:10.1016/j.febslet.2005.09.060
Actually, in mice deficient in GLUT-2 HYPERGLYCEMIA is the phenotype not hypoglycemia. As to the cause, the animals are unable to take up glucose in the liver because GLUT-2 is the major glucose receptor on hepatocytes.
References -
Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2
Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes
http://www.pnas.org/content/95/21/12317.full
The Bishop