# Assay Calculation of Cefatazidime inj in dried sodium carbonate free basis

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Ajesh
Assay Calculation of Cefatazidime inj in dried sodium carbonate free basis

If our HPLC assay gives a 99.4% cefatazidime in as is basis, then how we will calaculate the same in dried and sodium carbonate free basis with the following available data.

LOD - 9.18%
Na2CO3- 1.20%

Anand gupta
for dried basis calculation

for dried basis calculation

purity dried basis = purity as is basis X 100/100 - LOD

there fore, your purity on dried basis is 109.44%

for Na2 CO3 I actually dont Know but you can try with the above formula or try USP method for calculation

Thanks and regards,
Anand Gupta

Anandan
I agree with anand gupta.

I agree with anand gupta.
For first you should know, the standard what basis it’s qualified.
For Example(Standard as a Free Base)
Assay as HCl Salt = Assay as freebasex100
( 100-Chloride content)
Regards
Anandan

pattyFVS
dear sir,

dear sir,
If i have ceftazidime which the assay is 98,5% ceftazidime as dried basis and assay 72,5% ceftaxidime as on is basis (content of water 10,1 %; and content of sodium carbonate 16,3%).
if the dose in product is 1000 mg ceftazidime, how much the weight of waw material should be?

Thanks and regard,
patty