Some points on the topic of 'Innate Defence System'?

HI....as the topic is self explanatory so kindly help me in this regard. 

I am going to assume you are talking about the immune system, which is sometimes called innate because it is contained within a living organism. The component of cells that makes up this system play multiple roles, from the identification of foreign substances to the "building" of the proper response factors, to the recognition of these foreign substances and their eventual destruction.

This system is highly complex, containing arguably the most diverse collection of genes that are mixed and matched to create antibodies that recognize everything that enters our system.

The field of immunology is large, and the topics quite varied. Hope this helped.

I think innate immunity refers to systems controlled by anti-microbial peptides, neutrophils and macrophages to neutralize invading pathogens such as viruses and bacteria etc. Recognition is via Toll-Like Receptors and others to activate pro-inflammatory cytokines such as IL-1, IL-6 and TNFalpha via the NF-kB pathway. Neutrophils become chemoattracted towards the pathogen, attack it by secreting proteases, die and then get eaten by macrophages which remove debris to prevent the build up of necrotic material.

I think of these systems as a first line of defense and one that has older evolutionary origins than the adaptive immune system which is controlled by lymphocytes  to give the humoral and cellular immune responses that we all learn far more about in immunology classes.

Hi parvoman,

Thank you for the clarification. I completely missed the distinction.

And thank you for the nod towards antimicrobial peptides

The most important components of innate immunity are anatomical barriers like

SKIN which secretes sebum which also provides to waterproof the skin and also thought to have an anti-bacterial action bacteria need to invade the body in some way for infection to occur, there is some form of innate defence mechanism at each portal of entry to the body ,

MOUTH mucous membrane secretes saliva (having a enzyme Lysozyme) which is antibacterial thus fights bacteria ,

STOMACH, hydrochloric acidsufficiently low pH value  present in the gastric juices produced by the stomach lining kill most organisms entering the body

INTESTINE, Escherichia coli, Streptococci, and anaerobic Bacteroides contribute to the normal functioning of the gut.

UPPER RESPIRATORY TRACT,  the presence of hairs, or vibrissae, in the nose prevents large particles from entering the tract The stream of mucus(contains enzyme Lysozyme)that  traps smaller particles and is bactericidal .

EYE Blinking of eye and tears provide defence from irritants

I think the innate immune system is any part of the immune system that doesn't directly deal with adaptive immunity (antigen specific activation of T cells and B cells and the subsequent effects from those cells). Everrything else, including (but not limited to) anatomical barriers, APCs (including dendritic cells and macrophages), neutrophils, eosinophils, endothelia and sometimes epithelial responses to pathogens, antimicrobial peptides, toll like receptors . . .

The field is huge. Any one of these topics would make for a great writing point on innate immunity.

 (Personally, I study the release of lectins from endothelia that have a direct effect on viral glycoproteins. Another example of innate immunity).

Omai

Innate immunity is the natural immunity, produced during from birth, in this cells are involved..

U want to know about basic immunology please visit the website of DANA fFARBER CANCER INSTITUTE- ONLINE BOOK IS THERE.

The innate immune system comprises the cells and mechanisms that defend the host from infection by other organisms, in a non-specific manner. This means that the cells of the innate system recognize and respond to pathogens in a generic way, but unlike the adaptive immune system, it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life.

The innate system is thought to constitute an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and in primitive multicellular organisms. The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection and inflammation, through the production of chemical factors, including specialized chemical mediators, called cytokines. Activation of the complement cascade to identify bacteria, activate cells and to promote clearance of dead cells or antibody complexes. The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialized white blood cells. Activation of the adaptive immune system through a process known as antigen presentation.

Here is the useful link http://pathmicro.med.sc.edu/ghaffar/innate.htm

Here Immunology animation.. http://www.wpunj.edu/icip/sec/BIOimmuANIM.htm

Reference: en.wikipedia.org/wiki/Innate_immunity

This link seemed pretty informative...

<a href="http://allnutri.com/bid1592/innate+response.aspx">http://allnutri.com/bid1592/innate+response.aspx</a>