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IVIG

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Nikaein

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Please help! How can I get rid of IVIG drug given to a patient from the serum in order to be able to detect HLA antibodies?
Is anyone there to answere?

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Posted Oct 13, 2004, 5:27 AM
wwierda

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Nikaein said:
Please help! How can I get rid of IVIG drug given to a patient from the serum in order to be able to detect HLA antibodies?
Is anyone there to answere?


Since IVIG is purified human immunoglobulin, there is really no way to remove what is provided by IGIV and retain naturally produced Ig from a patient's serum. The IVIG has a half-life of 30 days. Historically, this created a problem with patients who seemingly converted to HIV+ after receiving IVIG, but in fact, this was only anti-HIV antibody from the IVIG and not a true viral infection.

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Posted Oct 13, 2004, 1:01 AM
Nikaein

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Unfortunately, most IVIG are both IgM and IgG. Both bind the monocytes and some B cells through FC receptor. Yes, they bind non-specifically and cause a high background. Other suggestions?

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Posted Oct 15, 2004, 22:30 PM
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