Award
 » Home » Genetics » Gene Delivery » telomerase
 
Solutions Search! The Customized Life Science Search Engine
Search Site
Search Suppliers
Search Internet
Search over 6000 life science websites specifically selected by our expert scientist moderators.

Other Topics
9/2/2008 02:05 AM
PEI PEGylation
2/4/2008 09:00 PM
Autism Spectrum Disorder ...
7/12/2007 09:18 PM
IDT and Agilent Combine E ...
2/8/2007 09:29 PM
Products for Gene Deliver ...
11/8/2006 04:50 AM
what are methods for gene ...
7/6/2006 06:33 AM
Special issue on Amphioxu ...
4/25/2005 02:43 PM
TREC sequence
1/4/2005 07:03 PM
Nano Container For Drug/G ...
Subscribet to topic
bottom of page RSS Feed Topic Feed
 telomerase [View Printable]
Dr.Behjati

Frog Egg

See
Similar
Scientists





Group: Member
Posts: 1
Joined: May 07, 2005







 Send a personal messsage to Dr.Behjati Reply with a quote from this post Go to the top of the page

Hello
I need some inhibitors of telomerase alternative splicing.
Whould you please kindly help me if you can?
.........................

 Posted May 08, 2005, 9:06 AM
Sandy

Frog Laureate

See
Similar
Scientists





Group: Member
Posts: 117
Joined: Nov 23, 2004







 Send a personal messsage to Sandy Reply with a quote from this post Go to the top of the page

Dr.Behjati said:

Hello
I need some inhibitors of telomerase alternative splicing.
Whould you please kindly help me if you can?


Check International Journal of Oncology volume 24, number 4
from April 2004 with ISSN 1019-6439.
for e.g. the following article:
Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. S.G. Gray, C.-N. Qian, K. Furge, X. Guo and B.T. Teh (Grand Rapids, MI, USA; Guangzhou, P.R. China) 751



.........................

Posted Jun 07, 2005, 15:18 PM
Richard Taylor

Staff

See
Similar
Scientists





Group: Guests
Posts: 118
Joined: Feb 01, 2005







 Go to homepage of Richard Taylor Send a personal messsage to Richard Taylor Reply with a quote from this post Go to the top of the page

What is it you are looking for here:

Are you looking for selevtive inhibitors of telomerase splice variants? eg. something that would inhibit hTERTalpha but not other telomerases?

Do you really need an inhibitor - or would an antisense approach to removing one alternative construct be feasible?

Are you asking for selective inhibitors of telomerase reverse transcriptase alternative splicing pathways?
.........................
Richard Taylor | http://www.biomarketing.co.uk

Posted Jun 10, 2005, 8:02 AM
Richard Taylor

Staff

See
Similar
Scientists





Group: Guests
Posts: 118
Joined: Feb 01, 2005







 Go to homepage of Richard Taylor Send a personal messsage to Richard Taylor Reply with a quote from this post Go to the top of the page

The page number for the above cited article is wrong (It's 733). The article is available online here:

http://147.52.72.117/IJO/2004/volume24/number4/773.pdf

I can't see the answer to your question within it though!
.........................
Richard Taylor | http://www.biomarketing.co.uk

Posted Jun 10, 2005, 8:08 AM
Behjati

Frog Egg

See
Similar
Scientists





Group: Member
Posts: 3
Joined: May 11, 2005







 Send a personal messsage to Behjati Reply with a quote from this post Go to the top of the page

Dear freinds

Thanks great for your replies.
I studied your answers.
I shouls say I really think that it is possible to induce some forms of alternatively splicied variants of telomerase without any activity, e.g alpha deletion is a dominant inhibitor of telomerase activity, and if we induce alternative splicing toward alpha deletion, we will reach the potential to reduce telomerase activity in tumors.

Thanks again.
Regards
.........................

Posted Jun 11, 2005, 9:25 AM
Richard Taylor

Staff

See
Similar
Scientists





Group: Guests
Posts: 118
Joined: Feb 01, 2005







 Go to homepage of Richard Taylor Send a personal messsage to Richard Taylor Reply with a quote from this post Go to the top of the page

What you're looking for is a regulator of the alternative splicing?

What stage are you at with this - thinking of ideas to apply for a grant?

Alternative splicing of telomerase occurs during development so such regulators do exist within humans - though they are not yet characterised.

Treat it as a "textbook" drug discovery process - in which you've identified a putatitive target from the literature.
.........................
Richard Taylor | http://www.biomarketing.co.uk

Posted Jun 12, 2005, 6:22 AM
Behjati

Frog Egg

See
Similar
Scientists





Group: Member
Posts: 3
Joined: May 11, 2005







 Send a personal messsage to Behjati Reply with a quote from this post Go to the top of the page

Dear Richard
You think in a right manner. I'm thimking to this, for a grant. I want to induce full length hTERT to alpha deletion, beta deletion, alpha +beta deletion, insertion variants. I mean I need variants without telomerase activity.
Thanks

.........................

Posted Jun 12, 2005, 6:14 AM
Behjati

Frog Egg

See
Similar
Scientists





Group: Member
Posts: 3
Joined: May 11, 2005







 Send a personal messsage to Behjati Reply with a quote from this post Go to the top of the page

Dear Richard Taylor

Today, I read your questions baout my asks, again. You asked me:( Are you looking for selevtive inhibitors of telomerase splice variants? eg. something that would inhibit hTERTalpha but not other telomerases?

Do you really need an inhibitor - or would an antisense approach to removing one alternative construct be feasible?

Are you asking for selective inhibitors of telomerase reverse transcriptase alternative splicing pathways?)

Would you please kindly let me know what are your approaches for every question? I mean what will be your suggestion, if I need selective inhibitors of telomerase alternative splicing pathway? Or, if I want to inhibit alpha deletion hTETR variant not others?

And finally, If I need to use anti-sence, How can I find the correct intron_exon boundaries of hTERT?
Can I find them by comparing the mRNA sequences of hTERT alternative spliced variants?

Thanks in advance.
Regards
.........................

Posted Aug 30, 2005, 7:00 AM
top of page

Forum Jump