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mice model and Chemical carcinogenesis

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DD

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C57BL/6 strain of mice are most responsive to complete epidermal carcinogenesis when dimethylbenzanthiacene (DMBA) is used compared to C3H and BALB/c mice. What mechanism or genetical predisaposition is involved to make C57BL/6 mice prone to skin cancer?
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Posted May 06, 2005, 20:19 PM
roudi

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DD said:
C57BL/6 strain of mice are most responsive to complete epidermal carcinogenesis when dimethylbenzanthiacene (DMBA) is used compared to C3H and BALB/c mice. What mechanism or genetical predisaposition is involved to make C57BL/6 mice prone to skin cancer?


It could be due to a series of mutations and SS18 genes common between human and mouse. Does anybody else have some information? I need to use C57Black mice for immunization and I don't want them to catch cancer and die in the middle of the experiment.
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Posted Aug 23, 2005, 0:32 AM
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