What is the role of TRANCE in autoimmunity? Any references?

antoonio said:

What is the role of TRANCE in autoimmunity? Any references?

TRANCE belongs to TNF superfamily cytokines, is a survival factor for activated dentritic cells and a key cytokine involved in osteoclast differentiation & activation, contributing to the pathologic bone loss.

Walsh MC, Choi Y. Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):251-63

antoonio said:

What is the role of TRANCE in autoimmunity? Any references?

The role of TRANCE in autoimmunity has thus far been shown in mouse models but that in humans has not been established or is ongoing. However, DC-based therapy of cancer patients has shown that TRANCE may be the culprit contributing to autoimmunity in responding patients.

Immunity. 2003 Dec;19(6):849-61.


Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin.

Ashcroft AJ, Cruickshank SM, Croucher PI, Perry MJ, Rollinson S, Lippitt JM, Child JA, Dunstan C, Felsburg PJ, Morgan GJ, Carding SR.

Wong BR et al. (1999) J. Leuko. Biol. vol. 65:715-724: TRANCE is a TNF family member that regulates DC and Osteoclast function.

I guess TRANCE is old nomenclature now. RANK-L is the preferred term and any ref's you need you should use RANK-L for searching. RANK-L is need for osteoclast development and for mammary gland development and for the development of some peripheral lymph nodes. Really any comprehensive review on RANK-L should be able to tell you all this and more. As far as I know, any mutations in RANK-L cause profound bone phenotypes but less pronouced immunological phenotypes.