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Stem Cell Hemotoxicity Testing

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DD
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Topic Started by DD
on 4/8/2005 22:19 PM   
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Conventional hematotoxicity testing involves measuring different mature blood-cell components, over time after administation of an agent. For proliferating systems, major toxicity does not occur in mature cells but in the cells responsible for producing the mature cells, namely the stem and progenitor cells for the lymphohematopoeitic system.
For stem cell hemotoxicity to play a role at all stages of drug development, the HALO ( Hematopoeitic/hematotoxicity Assays via Luminescence Output), was developed. Does anyone know the name of company/ies that provide Halo platforms?


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Carson O Genic
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Posted By Carson O Genic
on 6/23/2005 0:24 AM   
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Do you mean these guys?

http://www.hemogenix.com/index2.php



DD
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Posted By DD
on 6/23/2005 0:50 AM   
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Carson O'Genic said:
Do you mean these guys?

http://www.hemogenix.com/index2.php


Thank you so much for your help, I checked the site and this is definitely the company I was looking for.

Thanks again.




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Posted By Sandy
on 6/23/2005 19:51 PM   
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DD said:
Conventional hematotoxicity testing involves measuring different mature blood-cell components, over time after administation of an agent. For proliferating systems, major toxicity does not occur in mature cells but in the cells responsible for producing the mature cells, namely the stem and progenitor cells for the lymphohematopoeitic system.
For stem cell hemotoxicity to play a role at all stages of drug development, the HALO ( Hematopoeitic/hematotoxicity Assays via Luminescence Output), was developed. Does anyone know the name of company/ies that provide Halo platforms?


HALO exactly stands for Hematopoietic/Hemocytotoxicity Assay via Luminescence Output. HALO Tag fusion proteins are used in different sub-cellular locations: Nucleus, Mitochondria, Cytosol, etc. Cells can be labeled with fluorescence HaloTag ligand and images observed by fluorescent microscopes. The HaloTag technology is available by Promegawww.promega.com and is a new method of labeling target proteins within the cell that can be used in functional assays. It allows observing cells over long period of time so studies such as drug exposures can be done.



amruff
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Posted By amruff
on 8/2/2012 6:19 AM   
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 Greetings DD - I work for HemoGenix and would be more than happy to share information with you on the HALO assay. HALO is a highly predicitve, in vitro stem and progenitor cell hemotoxicity screening and testing platfrom for all stages of drug development and xenobiotics. Feel free to send me an e-mail and I can send you a flyer and product/service information. amrich@hemogenix.com 

 



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