We need to choose an appropriate vaccine model to immunize mice in order to measure B cell response under different controlled conditions. Are there T-cell dependent vs T-cell independent vaccines? Running both of these options in parallel would be best.

Here are a couple of papers that may help. Also, I'm going to move this post to Immunology to see if you can get an expert opinion.

http://jvi.asm.org/cgi/content/abstract/75/11/5141
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/110/6/2013
http://www.sciencemag.org/cgi/content/abstract/244/4908/1078

Omai