Morpholino Virology Publications

Alonso M, Stein DA, Thomann E, Moulton HM, Leong JC, Iversen P, Mourich DV. Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptide-conjugated morpholino oligomers. J Fish Dis. 2005 Jul;28(7):399-410.

Bok K, Cavanaugh VJ, Matson DO, González-Molleda L, Chang KO, Zintz C, Smith AW, Iversen P, Green KY, Campbell AE. Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome. Virology. 2008 Sep 8. [Epub ahead of print]

Burrer R, Neuman BW, Ting JPC, Stein DA, Moulton HM, Iversen PL, Kuhn P, Buchmeier MJ. Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models. J. Virol. 2007 Epub 2007 Mar 5.

Deas TS, Bennett CJ, Jones SA, Tilgner M, Ren P, Behr MJ, Stein DA, Iversen PL, Kramer LD, Bernard KA, Shi PY. In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus. Antimicrob Agents Chemother. 2007 May 7; [Epub ahead of print]

Deas TS, Binduga-Gajewska I, Tilgner M, Ren P, Stein DA, Moulton HM, Iversen PL, Kauffman EB, Kramer LD, Shi PY. Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication. J Virol. 2005 Apr;79(8):4599-609.

Dunlap KA, Palmarini M, Varela M, Burghardt RC, Hayashi K, Farmer JL, Spencer TE. Endogenous retroviruses regulate periimplantation placental growth and differentiation. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14390-5. Epub 2006 Sep 15.

Enterlein S, Warfield KL, Swenson DL, Stein DA, Smith JL, Gamble CS, Kroeker AD, Iversen PL, Bavari S, Muhlberger E. VP35 Knockdown Inhibits Ebola Virus Amplification and Protects against Lethal Infection in Mice. Antimicrob Agents Chemother. 2006 Mar;50(3):984-93.

Gabriel G, Nordmann A, Stein DA, Iversen PL, Klenk HD. Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus. J Gen Virol. 2008 Apr;89(Pt 4):939-48.

Ge Q, Stein D, Kroeker A, Iversen P, Chen J. Inhibition of influenza A virus production in vero cells with morpholino oligomers. Program and abstracts of the 44th Interscience Conference of Antimicrobial Agents and Chemotherapy; October 30-November 2, 2004; Washington, DC. Abstract V-1268.

Ge Q, Pastey M, Kobasa D, Puthavathana P, Lupfer C, Bestwick RK, Iversen PL, Chen J, Stein DA. Inhibition of Multiple Subtypes of Influenza A Virus in Cell Cultures with Morpholino Oligomers. Antimicrob Agents Chemother. 2006 Nov;50(11):3724-33. Epub 2006 Sep 11

Harris E, Holden KL, Edgil D, Polacek C, Clyde K. Molecular biology of flaviviruses. Novartis Found Symp. 2006;277:23-39; discussion 40, 71-3, 251-3.

Jubin R. Optimizing electroporation conditions for intracellular delivery of morpholino antisense oligonucleotides directed against the hepatitis C virus internal ribosome entry site. Methods Mol Med. 2004;106:309-22.

Jubin R, Vantuno NE, Kieft JS, Murray MG, Doudna JA, Lau JY, Baroudy BM. Hepatitis C Virus Internal Ribosome Entry Site (IRES) Stem Loop IIId Contains a Phylogenetically Conserved GGG Triplet Essential for Translation and IRES Folding. J Virol 2000 Nov 15;74(22):10430-10437

Kinney RM, Huang CY, Rose BC, Kroeker AD, Dreher TW, Iversen PL, Stein DA. Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers. J Virol. 2005 Apr;79(8):5116-28.

Lai SH, Stein DA, Guerrero-Plata A, Liao SL, Ivanciuc T, Hong C, Iversen PL, Casola A, Garofalo RP. Inhibition of Respiratory Syncytial Virus Infections With Morpholino Oligomers in Cell Cultures and in Mice. Mol Ther. 2008 Apr 29; [Epub ahead of print]

Lupfer C, Stein DA, Mourich DV, Tepper SE, Iversen PL, Pastey M. Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers. Arch Virol. 2008 May;153(5):929-37. Epub 2008 Mar 28.

Ly H, Nierlich DP, Olsen JC, Kaplan AH. Functional characterization of the dimer linkage structure RNA of Moloney murine sarcoma virus. J Virol. 2000 Nov;74(21):9937-45.

McCaffrey AP, Meuse L, Karimi M, Contag CH, Kay MA. A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice. Hepatology. 2003 Aug;38(2):503-8

Moulton HM, Fletcher S, Neuman BW, McClorey G, Stein DA, Abes S, Wilton SD, Buchmeier MJ, Lebleu B, Iversen PL. Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo. Biochem Soc Trans. 2007 Aug;35(Pt 4):826-8.

Neuman BW, Stein DA, Kroeker AD, Moulton HM, Bestwick RK, Iversen PL, Buchmeier MJ. Inhibition and escape of SARS-CoV treated with antisense morpholino oligomers. Adv Exp Med Biol. 2006;581:567-71. No abstract available.

Neuman BW, Stein DA, Kroeker AD, Churchill MJ, Kim AM, Kuhn P, Dawson P, Moulton HM, Bestwick RK, Iversen PL, Buchmeier MJ. Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers. J Virol. 2005 Aug;79(15):9665-76.

Neuman BW, Stein DA, Kroeker AD, Paulino AD, Moulton HM, Iversen PL, Buchmeier MJ. Antisense Morpholino-Oligomers Directed against the 5' End of the Genome Inhibit Coronavirus Proliferation and Growth. J Virol. 2004 Jun;78(11):5891-5899.

Paessler S, Rijnbrand R, Stein DA, Ni H, Yun NE, Dziuba N, Borisevich V, Seregin A, Ma Y, Blouch R, Iversen PL, Zacks MA. Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers. Virology. 2008 Jul 5;376(2):357-70. Epub 2008 May 12.

Patel D, Opriessnig T, Stein DA, Halbur PG, Meng XJ, Iversen PL, Zhang YJ. Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication. Antiviral Res. 2008 Feb;77(2):95-107. Epub 2007 Oct 4

Raggo C, Ruhl R, McAllister S, Koon H, Dezube BJ, Fruh K, Moses AV. Novel cellular genes essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus. Cancer Res. 2005 Jun 15;65(12):5084-95.

Sample R, Bryan L, Long S, Majji S, Hoskins G, Sinning A, Olivier J, Chinchar VG. Inhibition of iridovirus protein synthesis and virus replication by antisense morpholino oligonucleotides targeted to the major capsid protein, the 18 kDa immediate-early protein, and a viral homolog of RNA polymerase II. Virology. 2006 Oct 2; [Epub ahead of print]

Silvestri LS, Ruthel G, Kallstrom G, Warfield KL, Swenson DL, Nelle T, Iversen PL, Bavari S, Aman MJ. Involvement of Vacuolar Protein Sorting Pathway in Ebola Virus Release Independent of TSG101 Interaction. J Infect Dis. 2007 Nov 15;196 Suppl 2:S264-70.

Smith AW, Iversen PL, O'Hanley PD, Skilling DE, Christensen JR, Weaver SS, Longley K, Stone MA, Poet SE, Matson DO. Virus-specific antiviral treatment for controlling severe and fatal outbreaks of feline calicivirus infection. Am J Vet Res. 2008 Jan;69(1):23-32.

Smith AW, Matson DO, Stein DA, Skilling DE, Kroeker AD, Berke T, Iversen PL. Antisense treatment of caliciviridae: an emerging disease agent of animals and humans. Curr Opin Mol Ther. 2002 Apr;4(2):177-84.

Stein DA, Huang CY, Silengo S, Amantana A, Crumley S, Blouch RE, Iversen PL, Kinney RM. Treatment of AG129 mice with antisense morpholino oligomers increases survival time following challenge with dengue 2 virus. J Antimicrob Chemother. 2008 Sep;62(3):555-65. Epub 2008 Jun 19.

Stein DA, Skilling DE, Iversen PL, Smith AW. Inhibition of Vesivirus infections in mammalian tissue culture with antisense morpholino oligomers. Antisense Nucleic Acid Drug Dev. 2001 Oct;11(5):317-25.

Stone JK, Rijnbrand R, Stein DA, Ma Y, Yang Y, Iversen PL, Andino R. A morpholino oligomer targeting highly conserved internal ribosome entry site sequence is able to inhibit multiple species of picornavirus. Antimicrob Agents Chemother. 2008 Jun;52(6):1970-81. Epub 2008 Mar 17.

Vagnozzi A, Stein DA, Iversen PL, Rieder E. Inhibition of foot-and-mouth disease virus in cell cultures with antisense Morpholino oligomers. J Virol. 2007 Nov;81(21):11669-80. Epub 2007 Aug 29.

van den Born E, Stein DA, Iversen PL, Snijder EJ. Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture. J Gen Virol. 2005 Nov;86(Pt 11):3081-90.

Wang F, Bi X, Chen LM, Hew CL. ORF018R, a highly abundant virion protein from Singapore grouper iridovirus, is involved in serine/threonine phosphorylation and virion assembly. J Gen Virol. 2008 May;89(Pt 5):1169-78.

Warfield KL, Swenson DL, Olinger GG, Nichols DK, Pratt WD, Blouch R, Stein DA, Aman MJ, Iversen PL, Bavari S. Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers. PLoS Pathog. 2006 Jan;2(1):e1. Epub 2006 Jan 13.

Warfield KL, Panchal RG, Aman MJ, Bavari S. Antisense treatments for biothreat agents. Curr Opin Mol Ther. 2006 Apr;8(2):93-103.

Wells SI, Francis DA, Karpova AY, Dowhanick JJ, Benson JD, Howley PM. Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways. EMBO J. 2000 Nov 1;19(21):5762-71.

Yuan J, Stein DA, Lim T, Qiu D, Coughlin S, Liu Z, Wang Y, Bouch R, Moulton HM, Iversen PL, Yang D. Inhibition of Coxsackievirus B3 in Cell-cultures and in Mice by Peptide-Conjugated Morpholino Oligomers Targeting the IRES. J Virol. 2006 Sep 20; [Epub ahead of print]

Zhang B, Dong H, Stein DA, Shi PY. Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance RNA/RNA base pairings. Virology. 2008 Oct 6. [Epub ahead of print]

Zhang B, Dong H, Stein DA, Iversen PL, Shi PY. West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions. Virology. 2008 Mar 30;373(1):1-13. Epub 2008 Feb 6.

Zhang YJ, Bonaparte RS, Patel D, Stein DA, Iversen PL. Blockade of viral interleukin-6 expression of Kaposi's sarcoma-associated herpesvirus. Mol Cancer Ther. 2008 Mar;7(3):712-20.

Zhang YJ, Wang KY, Stein DA, Patel D, Watkins R, Moulton HM, Iversen PL, Matson DO. Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers. Antiviral Res. 2006 Jun 14; [Epub ahead of print]

Zhang YJ, Stein DA, Fan SM, Wang KY, Kroeker AD, Meng XJ, Iversen PL, Matson DO. Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers. Vet Microbiol. 2006 Jul 11; [Epub ahead of print]

Morpholino publications cataloged at: pubs.gene-tools.com