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Duration of Morpholino activity in a mouse

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jonmoulton

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"For example, we have observed continued exon skipping in the dystrophin transcript up to 14 weeks after a single intramuscular injection of a morpholino antisense molecule with concomitant expression of a modified dystrophin in the treated muscle of the dystrophic mdx mouse (Wells et al., unpublished)."

From: Wells DJ. Gene doping: the hype and the reality. Br J Pharmacol. 2008 Jun;154(3):623-31. Epub 2008 Apr 21.

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Jon D. Moulton, Ph.D. Gene Tools, LLC www.gene-tools.com

Posted May 29, 2008, 18:43 PM
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