Hi,
In certain immune cells in a geneticaly manipulated mice I am observing elevated amounts of Active caspase 3 & also higher BrdU incorporation at the same time, compared to the same cells from an unmanipulated mice. Also these cells are less in number in the manipulated mice compared to their number in the unmanipulated ones. Can anybody suggest some literature explaining this apparently paradoxical event.
Thanks,
Avijit

Can you check whether the following helps!!!

The American Journal of Gastroenterology
Volume 103 Issue 4 Page 825-837, April 2008

This is the paper. If you can not find it, send me your email address, I shall send that paper to you

(Am J Gastroenterol 2008;103:825837)
ORIGINAL CONTRIBUTIONS
Esophagus
Statins Inhibit Proliferation and Induce Apoptosis in Barrett's Esophageal Adenocarcinoma Cells
Olorunseun O. Ogunwobi, Ph.D.22Biomedical Research Centre, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom, and Ian L. P. Beales, M.D.1,21Gastroenterology Department, Norfolk and Norwich University Hospital, Norwich, United Kingdom2Biomedical Research Centre, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom1Gastroenterology Department, Norfolk and Norwich University Hospital, Norwich, United Kingdom and 2Biomedical Research Centre, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom
Reprint requests and correspondence: Ian L. P. Beales, Biomedical Research Centre, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, NR4 7TJ, United Kingdom.
(Am J Gastroenterol 2008;103:825837)

There is a bunch of literature from the Mike Lenardo, Doug Green, one of my papers, and several other groups (mostly in terms of T cell biology) that show simultaneous proliferation (enhanced S-phase/TdT uptake or BrdU inc) and cell death (hypodiploidy/caspase activation/mit pot reduction). In fact, Mike Lenardo goes so far as to suggest that high activation goes concomitantly with enhanced cell death in these cells.