Award
 Refer a Friend  Bookmark us  Link To Us  Home
My Bench Space Protocols Featured Products Win Favorites News & Jobs Events My Alerts
 
Solutions Search! The Customized Life Science Search Engine
Search Site
Search Suppliers
Search Internet
 Search over 6000 life science websites specifically selected by our expert scientist moderators.

BUZme
  bottom of page
Subscribet to topic

 Immunology [View Printable]
amaranna6

Frog Egg

Avatar of amaranna6 		See
Similar
Scientists


Group: Member
Posts: 9
Joined: Aug 10, 2007
 Send an email to amaranna6 Send a personal messsage to amaranna6 Reply with a quote from this post Go to the top of the page
Is it possible to block complement activation at specific organ of the body?
.........................
Just a slip, Not a fall...
 Posted Apr 07, 2008, 14:55 PM
krihol

Frog Laureate

Avatar of krihol 		See
Similar
Scientists


Group: Member
Posts: 42
Joined: Jan 04, 2007
 Send an email to krihol Send a personal messsage to krihol Reply with a quote from this post Go to the top of the page
It is really hard to answer your question, since it depends of what activation you would like to block. Any in particular?
.........................
Posted Apr 08, 2008, 15:40 PM
amaranna6

Frog Egg

Avatar of amaranna6 		See
Similar
Scientists


Group: Member
Posts: 9
Joined: Aug 10, 2007
 Send an email to amaranna6 Send a personal messsage to amaranna6 Reply with a quote from this post Go to the top of the page
Yes. I want block C4 activation. Is it possible?
.........................
Just a slip, Not a fall...
Posted Apr 09, 2008, 8:19 AM
krihol

Frog Laureate

Avatar of krihol 		See
Similar
Scientists


Group: Member
Posts: 42
Joined: Jan 04, 2007
 Send an email to krihol Send a personal messsage to krihol Reply with a quote from this post Go to the top of the page

You can try to create a single-chain Fv antibody against C4. It has been done for C5 see reference below. The flip side is that severe side effects might occur in vivo.

Thomas TC, Rollins SA, Rother RP et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol1996; 33:13891401
.........................
Posted Apr 09, 2008, 20:19 PM
verghi

Frog Egg

Avatar of verghi 		See
Similar
Scientists


Group: Member
Posts: 1
Joined: Apr 22, 2008
 Send an email to verghi Send a personal messsage to verghi Reply with a quote from this post Go to the top of the page
krihol said:

You can try to create a single-chain Fv antibody against C4. It has been done for C5 see reference below. The flip side is that severe side effects might occur in vivo.

Thomas TC, Rollins SA, Rother RP et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol1996; 33:13891401
.........................
hirve
Posted Apr 22, 2008, 8:28 AM
top of page
Forum Jump