Here is an interesting article.
The biological impact of
mass-spectrometry-based proteomics
Benjamin F. Cravatt1,2, Gabriel M. Simon1,2 & John R. Yates III1
In the past decade, there have been remarkable advances in proteomic technologies. Mass spectrometry
has emerged as the preferred method for in-depth characterization of the protein components of biological
systems. Using mass spectrometry, key insights into the composition, regulation and function of molecular
complexes and pathways have been gained. From these studies, it is clear that mass-spectrometry-based
proteomics is now a powerful hypothesis-generating engine that, when combined with complementary
molecular, cellular and pharmacological techniques, provides a framework for translating large data sets into
an understanding of complex biological processes.


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http://www.nature.com/nature/supplements/insights/proteins/index.html