I'm thinking about doing some analysis of a gene's enhancer / promoter region and was wondering how best to go about it.

Previously I would have looked for a human genomic library, done Southern using a probe to the coding sequence (lysyl oxidase - also known as LOX) to pick a bacterial colony containing the plasmid with the LOX fragment of interest. Then sequenced and performed PCR to isolate the 2-3Kb region of interest which would then be cloned upstream of a reporter gene in another plasmid to allow analysis of enhancer / promoter activity.

Is this still the way to do it or am I a dinosaur?

Have found out that there is a BAC clone for this. This should make it easier.

Comments, any experience out there?