New module brings sensitivity of Ovation RNA Amplification Systems to Affymetrix GeneChip Exon and Gene ST Array analysis

San Carlos, Calif.January 8, 2008NuGEN Technologies Inc., a privately held company that develops and commercializes nucleic acid amplification and labeling systems, announced today the launch of the WT-Ovation Exon Modulethe key component of a solution that enables life scientists to investigate small and difficult clinical tissue samples in exon and gene-level expression analysis studies. The comprehensive solution is designed to enable powerful amplification of precious RNA for analysis using Affymetrix GeneChip Exon and Gene ST Arrays.

The WT-Ovation Exon Module is the centerpiece of NuGENs complete, end-to-end workflow for fast, sensitive, and robust whole transcriptome amplification, ST-cDNA generation, fragmentation, and labeling. Other components of the solution include the WT-Ovation Pico or FFPE RNA Amplification Systems, and the FL-Ovation cDNA Biotin Module V2 for fragmentation and labeling of the cDNA targets. This easy-to-automate workflow enables researchers to transform as little as 100 pg of total RNA into targets for hybridization to Affymetrix GeneChip Exon and Gene ST Arrays.

The comprehensive solution enables exon-level global gene expression interrogation of a broad range of tissue specimens such as FFPE (formalin-fixed, paraffin-embedded), LCM (laser-captured, micro-dissected), fine-needle aspirates, sorted cells, frozen tissue samples, and others. This versatility will help unlock the vast archives of samples amassed as the result of years of clinical testing.

The Affymetrix GeneChip Exon ST Array platform has made possible two complementary levels of analysis at a whole-genome scalegene expression and alternative splicingallowing researchers to investigate gene expression at the level of transcript diversity, noted Sue Pandey, PhD, NuGEN Technologies vice president of commercial operations. Until today, sample preparation and access to difficult clinical specimens has been a challenge. The powerful combination of NuGEN sample preparation technology and the GeneChip Exon ST platform addresses a significant need in clinical research, and opens doors for potential discoveries in disease mechanism and pathology.

The NuGEN WT-Ovation Exon Module is currently available for ordering. For pricing and availability of all Ovation products, customers should contact NuGEN Technologies at 888-654-6544, custserv@nugeninc.com, or visit the NuGEN website at www.nugeninc.com.

About NuGEN
NuGEN Technologies, Inc. (www.nugeninc.com), based in San Carlos, CA, is focused on the development and commercialization of sensitive, rapid, and high-throughput amplification and labeling systems to enable the comprehensive analysis and discovery of biological mechanisms, cellular responses, and disease pathologies.
NuGEN and Ovation are registered trademarks of NuGEN Technologies, Inc. SPIA, Ribo-SPIA, WT-Ovation, FL-Ovation, and Imagine More From Less are trademarks or service marks of NuGEN Technologies, Inc. All other marks are the property of their respective owners