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 gene association studies [View Printable]
Amritha Nair

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was wondering what kind of PCR based mutation detection methods would be used in gene association studies?
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 Posted Jan 03, 2008, 14:44 PM
Tony Rook

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Amritha Nair -

PCR-SSCP (Single-strand conformation polymorphism) analysis is commonly used for mutation detection. Here are few background references to get you started...


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Hayashi K. PCR-SSCP: a method for detection of mutations. Genet Anal Tech Appl. 1992 Jun;9(3):73-9.

Abstract:
PCR-SSCP (polymerase chain reaction-si