ID50 & ED50

HOW DO U FIND ID50 AND ED50 VALUE OF A DRUG. HOW IT IS USEFUL FOR A DOCTOR

LD50 can find out by acute toxicity in rat or mice and EC 50 can find from efficacy dose of the drug. During acute toxicity study only from range of the dose we can calculate EC50. By LD50 doctore can know the lethal dose of the drug and precaution can be taken during dose given

The ID50 value is the concentration of the drug that binds 50% of the maximum binding to that drug's target receptor. The ED50 value is the concentration of the drug that produces 50% of the maximum response (as compared to binding). These are often different especially for agonist drugs, which has given rise to the concept of spare receptors because many agonist drugs have an ED50 that is much less than their ID50.

In general, doctors don't need to know these terms, but if you wanted to check what they are you can look in the IUPHAR database ( http://www.iuphar-db.org/index.jsp ) and then search for your specific ligand (drug - generic name) or look up its target receptor where you'll see a list of agonists and antagonist ligands (eg. for 5-HT1A receptor - http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2310 ).

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