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Status: Frog Egg
Frog Egg
Topic Started by r.etges
on 2/2/2005 10:53 AM   
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where can I obtain 20 - 50 mg piclamilast (RP 73401; 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide) as a positive control for our topical formulation trial of PDE4A inhibitors? Thanks, Robert Etges


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Posted By vanishing
on 5/7/2005 16:54 PM   
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I have found two sources in Pubmed:

1.) Quote: "Piclamilast was provided by Aventis Pharmaceuticals"
Zhao et al., (2003) Inhibitor Binding to Type 4 Phosphodiesterase (PDE4) Assessed
Using [3H]-Piclamilast and [3H]-Rolipram.
JPET Fast Forward. Published on January 24, 2003 as DOI:10.1124/jpet.102.047407

2.) Quote: " N-(3,5-dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide (piclamilast) was synthesized by Altana Pharma GmbH (Konstanz, Germany). "
Parrella et al., (2004) Phosphodiesterase IV Inhibition by Piclamilast Potentiates the Cytodifferentiating Action of Retinoids in Myeloid Leukemia Cells
J. Biol. Chem., Vol. 279, Issue 40, 42026-42040, October 1, 2004

Debbie Reed Bietz
United States

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Posted By Debbie Reed Bietz
on 6/25/2012 9:25 AM   
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Is this the Bob Etges from the University of Cincinnati who studied under Dr. Mukkada? If so, This is Deb Bietz. It would be great to talk to you if you have the time.



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