The National Human Genome Research Institute and the National Institute of Mental Health have set aside $3.1 million to create a coordinating center to support a program that will use population-based studies to determine the epidemiologic architecture of genetic variants associated with complex diseases.



Part I Overview Information

Department of Health and Human Services

Participating Organizations
National Institutes of Health (NIH) (http://www.nih.gov/)

Components of Participating Organizations
National Human Genome Research Institute (NHGRI)
(http://www.genome.gov/)
National Institute of Mental Health (NIMH)
(http://www.nimh.gov/)

Title: Epidemiologic Investigation of Putative Causal Genetic VariantsCoordinating Center (U01)


Request For Applications (RFA) Number: RFA-HG-07-015

Catalog of Federal Domestic Assistance Number(s)
93.172, 93.242

Key Dates

Release Date: August 17, 2007
Letter of Intent Receipt Date: October 19, 2007
Application Receipt Date: November 19, 2007
Peer Review Date: February/March 2008
Council Review Date: May 2008
Earliest Anticipated Start Date: July 1, 2008
Expiration Date: November 20, 2007


Executive Summary

The purpose of this funding opportunity is to provide support for a Coordinating Center (CC) to serve as a centralized resource to facilitate and support the investigation, in well-characterized population studies, of genetic variants identified as potentially causally associated with complex diseases in genome-wide association (GWA) and other genetic studies, with the aim of widespread sharing of the resulting population-based descriptive and association data to accelerate the understanding of genes related to complex diseases.

The total amount to be awarded over the four-year period of this RFA is $3.1 million.

It is anticipated that one award will be made under this RFA.

This RFA will use the U01 Cooperative Agreement award mechanism.

Eligible organizations include: Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Eligible agencies of the Federal government; and Faith-based or community based organizations.

Eligible principal investigators include individuals with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

Applicants may submit more than one application, provided they are scientifically distinct.

See Section IV.1 for application materials.

Telecommunications for the hearing impaired is available at: TTY 301-451-0088



For complete grant application information please link below:


RFA-HG-07-015 - Epidemiologic Investigation of Putative Causal Genetic VariantsCoordinating Center (U01)