The following was emailed to me via one of the many lists I belong to:
Version 20 of the Reactome Knowledgebase has been released and is accessible at http://www.reactome.org!
Reactome is a curated knowledgebase developed and maintained by the Reactome Knowledgebase team (Lincoln Stein's group at CSHL and Ewan Birney's group at European Bioinformatics Institute). Reactome covers human biological processes ranging from basic pathways of metabolism to complex events such as hormonal signaling and apoptosis. The information in Reactome is provided by expert bench biologists, and edited and managed as a relational database by the Reactome staff. New material is peer-reviewed and revised as necessary before publication to the web. Reactome entries are linked to corresponding ones in NCBI, Entrez Gene, RefSeq, OMIM, Ensembl genome annotations, HapMap, UCSC Genome Browser, KEGG, ChEBI and Gene Ontology (GO).
New topics released in Version 20 are Fibroblast Growth Factor Receptor (FGFR) signaling, Epidermal Growth Factor Receptor (EGFR) signaling under signaling pathways, Gap junction trafficking under cell biology, and Porphyrin metabolism, Digestion of dietary carbohydrate and lipid under metabolic pathways. Additional events for HIV REV protein interactions, and Influenza virus RNP assembly have been added to corresponding infectious disease pathways.
The standard display feature allows the user to choose the focus species annotations - curated (for human) and electronically inferred (for 22 other species). Updated release statistics and the Editorial Calendar are available. A SOAP based Web Services API is available aong with other resources to access the Reactome data from Download page. As before, Reactome data can be exported in SMBL, Protégé, and BioPAX level 2 formats.
Like everything in Reactome, these downloaded and exported materials can be reused and redistributed freely. For questions and comments please reply to this message or write to help@reactome.org.