Hello, all!
Could anybody help me to elucidate the role of TGFbeta?
I know that Treg and Ti use it to downregulate the responce to antigens. But this cytokine releases into the environment, where many different T cells exist. Does it always suggests that TGFbeta mediated suppression is nonspecific and acts as a simple downregulator of the total Teff cells activity.
Or some degree of specificity nethertheless exists?

Hi
I am not so mfamilier with T cells but as I can TGFbeta has got some specificity towards Treg .
I found an article that maybe would be somewhat of help for you
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed
Guy

Thank you for your interest! It`s great that there is a place in the net where one can comunicate with other scientists!
...But the reference does not work..
Could you please type the author and the tittle?