Can anybody provide me a good review on member of the subclass III family of receptor tyrosine kinases. Plz mail me at firozsrl@gmail.com
Thanks

Firoz, What exactly are you looking for? I have determined the crystal structures of the intracellular kinase domains for these receptors. That is the business end of the molecule, but perhaps you are interested in the extracellular ligand bindng domains. For some good reads I recommmed:

Heldin, C.-H. (1995). Dimerization of cell surface receptors in signal transduction Cell 80, 213-223.

Hubbard, S.R., Mohammadi, M., and Schlessinger, J. (1998). Autoregulatory mechanisms in Protein-tyrosine Kinases, J. Biol. Chem., 273, 11987-11990.

Hubbard, S.R., and Hill, J.H. (2000). Protein tyrosine kinase structure and function. Annu. Rev. Biochem. 69, 373-398.

I might have some PDFs if you can't access these. I just searched PubMed and I see your dillemma - there is not a very good entry point into the field. The "dimerization" paper above is pretty good as that is how these receptos activate themselves

Cliff

Dear Cliff,
Thanks for the message, well i was looking for some review artcile about various class III receptor kinases that plays an important role in cell signalling.
I would be glad to receive the pdf files which you have suggested me .
Looking forward for your reply
Firoz

Firoz, I don't mean to be narrow-minded, but I think that the most important Type III receptor kinases are c-Kit, Flt-3 and PDGFR. Mutations in c-Kit can cause stomach cancers among others, and I have dtermined the 3D structure of the kinase domain both in its active state and inactove state as well as with the cancer drug Gleevec bound. I attach PDFs of those two papers - some of the references mau be a good place for you to start.

cliff

P.S. I am having trouble attaching the PDF as they are too large - I will speak with the Web guys aboot this. Let me try your gmail account