http://www.newsrx.com/newsletters/Vaccine-Weekly/2006-05-10/051020063332VW.html

Robust HIV-specific immune responses were induced by DNA vaccine prime followed by attenuated recombinant vaccinia virus (LC16m8 strain) boost.
"Recombinant vaccinia virus-based vaccine combined with DNA vaccine has produced a protective immune response against HIV infection in non-human primates. In this study, we explored the immunogenicity of a recombinant vaccinia virus (LC16m8 strain), which has been used in children without severe side effects," scientists in Japan report.

"The vaccinia virus expressing an HIV89.6 env gene (vLC-Env) atone or combined with a DNA vaccine expressing the HIV89.6 env gene (pCAG-Env) was characterized in BALB/c mice," said...