What is that ALP

I think this antibodies are produce aganist the fetues?

if a female during pregent this ALP produced then she is aborted. second time she conceived the secondaey immune
response will take place?.please answer the Question

It is an autoimmune disease. ALP can be used as APS that is Antiphospholipid syndrom. In this case auto antibodies to phospholipids can be produced in human (more particularly in women). During the pregnacy, these antibodies can cause pregnacy loss by many ways. Different openions are existing about the mechanism...But research is still undergoing.

krishnaraj.T said:

What is that ALP I think this antibodies are produce aganist the fetues? if a female during pregent this ALP produced then she is aborted. second time she conceived the secondaey immune response will take place?.please answer the Question

Actually, if a women with APLAS (Antiphospholipid antibody syndrome) becomes pregnant the antibodies cause clot formation in the placental blood vessels and potentially in the fetal blood vessels leading to a miscarriage. The likelihood of this appears to remain the same in first and subsequent pregnancies.
Any woman who has two or more miscarriages in the late first to early second trimester with no other obvious causes, should be tested for APLAS as it is more common than generally thought.

It is an autoimmune disease and is classified as a subset of Systemic Lupus Erythematosus - as a result it is sometimes called Lupus Anticoagulant. One of the more common variants is labeled as Anticardiolipin. In all cases of APLAS the autoimmune antibodies bind to the various phospholipids which make up the cell membranes of the endothelial cells in the blood vessels. And, the exact identity of those phosphlipids varies between arteries and veins. As an aside; venous clot forming Lupus is more common then the arterial variety. The exact nature of the binding epitopes is not know to me but is likely to involve the proteins and saccharides on t he cell surface as well.

Lubrol880 said:

krishnaraj.T said: What is that ALP I think this antibodies are produce aganist the fetues? if a female during pregent this ALP produced then she is aborted. second time she conceived the secondaey immune response will take place?.please answer the Question Actually, if a women with APLAS (Antiphospholipid antibody syndrome) becomes pregnant the antibodies cause clot formation in the placental blood vessels and potentially in the fetal blood vessels leading to a miscarriage. The likelihood of this appears to remain the same in first and subsequent pregnancies. Any woman who has two or more miscarriages in the late first to early second trimester with no other obvious causes, should be tested for APLAS as it is more common than generally thought. It is an autoimmune disease and is classified as a subset of Systemic Lupus Erythematosus - as a result it is sometimes called Lupus Anticoagulant. One of the more common variants is labeled as Anticardiolipin. In all cases of APLAS the autoimmune antibodies bind to the various phospholipids which make up the cell membranes of the endothelial cells in the blood vessels. And, the exact identity of those phosphlipids varies between arteries and veins. As an aside; venous clot forming Lupus is more common then the arterial variety. The exact nature of the binding epitopes is not know to me but is likely to involve the proteins and saccharides on t he cell surface as well.

Yes the APLAS cause the pregncy loss in women associated with thrombosis. It is also can cause fetal death in late gestational age. This manifestation is too depend the thrombotic episode. More interestingly, the thrombus formation in placenta remains a important factor for the fetal loss (Velayuthaprabhu et al., 2007; AJRI).