Post-Doctoral Research Fellow (ML 24677)
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Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference!
About the Department
A highly qualified and motivated post-doctoral research fellow is sought to join the laboratory of Dr. Sunil Hingorani at Fred Hutchinson Cancer Research Center in Seattle, WA. Our laboratory studies the molecular and cellular origins of pancreas cancer. Pancreatic ductal adenocarcinoma (PDA) is a nearly uniformly lethal disease that defies all forms of conventional chemo- and radiotherapy. To answer fundamental questions about the biology of PDA we have turned to genetically engineered mouse models. By directing the expression of key mutations in specific oncogenes and tumor suppressor genes to the mouse pancreas, we have developed models that faithfully mimic the spectrum of human PDA from its earliest preinvasive lesions to locally invasive and widely metastatic disease (for examples, see Cancer Cell 4:437-450, 2003; Cancer Cell 7:469-483, 2005; Cancer Cell 11:229-243, 2007). Our goals are to use these models to understand fundamental mechanisms of disease pathogenesis and to design and test strategies for early detection and for treatment and chemoprevention.
Four broad areas of inquiry are currently being pursued: 1) continuing investigations into the molecular requirements for disease progression and, in particular, mechanisms driving the unusually high penchant for metastasis; 2) generation of additional genetically-engineered mice incorporating recent findings on mutations of potential importance in disease pathogenesis; 3) investigations into the cell-of-origin for preinvasive and invasive pancreas cancer and the possibility that it may function as a “cancer stem cell”; 4) integrated analyses of serum, plasma, tissue, and isolated primary cell lines to identify biomarkers of early disease and potential therapeutic targets.
A Ph.D. in the field of molecular biology, biomedical engineering, biochemistry, biophysics, or genetics and a demonstrated track record of productive research experience are required. The successful candidate must have excellent communication and organizational skills, the ability to develop creative approaches to experimental design and be able to function independently and work collaboratively.
The candidate must also be experienced in essential techniques in molecular and cellular biology including cloning, transfection/infection of cells, PCR, Southern/Northern/Western blotting, tissue culture, immunohistochemistry and immunofluorescence. Candidates with experience in advanced imaging techniques, gene targeting and the generation of genetically engineered mice, or experience with flow sorting of cells and tissue stem cells are desired.
Pay,Benefits, & Work Schedule
Salary based on the NIH scale + excellent benefits
How To Apply
Please visit our website at http://www.fhcrc.org/careers and reference job number 24677. If you have not previously registered with us you will be prompted to do so; otherwise, please follow the online directions to submit your resume and/or cover letter.
AND please also send a cover letter describing your research interests and qualifications, a letter of recommendation from your primary research advisor and CV to Melissa Loomis (firstname.lastname@example.org) with the subject header "ML-24677, Post-Doc [Your Name]".
Equal Employment Opportunity
The Fred Hutchinson Cancer Research Center and The Seattle Cancer Care Alliance are equal opportunity employers, committed to workforce diversity.
Seattle , WA
Deadline: Contact employer
For more details
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