gene therapy for HIV [View Printable]
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dennsi
Group: Member
Posts: 10
Joined: Dec 04, 2004
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Is there any gene therapy for HIV? |
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| Posted Dec 18, 2004, 14:50 PM |
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David E
Group: Member
Posts: 263
Joined: Sep 29, 2004
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| dennsi said: | | Is there any gene therapy for HIV? |
Here is a resource for information on all AIDS related clinical trials. http://aidsinfo.nih.gov/clinical_trials/ |
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| Posted Dec 20, 2004, 22:26 PM |
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Carson O Genic
Group: Member
Posts: 152
Joined: Jun 22, 2005
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I know a company called VIRxSYS has had some good (very early) results. |
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| Posted Jun 29, 2005, 19:21 PM |
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TaqMan
Group: Member
Posts: 13
Joined: Jun 29, 2005
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As far as I know there is a group working in Africa with some people that are imune to AIDS, they discover that a mutation in a certain gene is related to the imunity. |
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| Posted Jun 29, 2005, 19:55 PM |
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bsengez
Group: Member
Posts: 42
Joined: Mar 29, 2007
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Is there anyone studying on HIV gene theraphy in this forum? |
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| Posted Jul 19, 2007, 22:13 PM |
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parvoman
Group: Member
Posts: 272
Joined: Jul 28, 2005
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I was at a Gene Therapy Conference last year and there was a guy there from the Rossi Lab (City of Hope, somewhere in California). They were just starting a clinical trial using lentivitus vectors to deliver microRNA expression cassettes to CD34 positive stem cells (from the bone marrow). Daughter blood cells from these progenitors would express the microRNA which specifically targets multiple HIV target RNA structures (I forget which exactly, but for example the Tat response element as well as one or more of the translated mRNAs) to help reduce any escape mutants that would otherwise arise.
It looked very promising indeed.
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| Posted Jul 20, 2007, 22:19 PM |
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bsengez
Group: Member
Posts: 42
Joined: Mar 29, 2007
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Can you remember his name? I'm also working on HIV gene theraphy, but I newly started. I'm also working on tat gene. I'm not at the level of lentiviral vector designing, but after cloning I will start. It can be very helpful for me to talk with them.
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| Posted Jul 26, 2007, 12:46 PM |
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crozUT
Group: Member
Posts: 2
Joined: Jul 19, 2007
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I'm currently working on CNV and its connection with HIV expression. |
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| Posted Aug 02, 2007, 15:26 PM |
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parvoman
Group: Member
Posts: 272
Joined: Jul 28, 2005
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| bsengez said: | Can you remember his name? I'm also working on HIV gene theraphy, but I newly started. I'm also working on tat gene. I'm not at the level of lentiviral vector designing, but after cloning I will start. It can be very helpful for me to talk with them.
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I just pulled this out of PubMed: Lentiviral-mediated delivery of siRNAs for antiviral therapy. Gene Ther. 2006 Mar;13(6):553-8. Review. Weinberg MS, Villeneuve LM, Ehsani A, Amarzguioui M, Aagaard L, Chen ZX, Riggs AD, Rossi JJ, Morris KV. The post-doc who gave the presentation (ESGT 2006 Athens) was Dr. Aagaard. His talk was specifically on the design of microRNAs that target multiple viral (HIV) targets. The Rossi lab is probably the world leader in anti-viral RNAi applications. |
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| Posted Aug 05, 2007, 2:34 AM |
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