A drug usually recommended by the emminent doctors to help women who could not give birth to a child..is "LETROZOLE" has been identified as harmful effects..
Letrozole is approved for use only in postmenopausal women with breast cancer. Nevertheless, Swiss drug manufacturer Novartis cited evidence that some doctors have prescribed it as a fertility treatment because it suppresses estrogen and can promote ovulation. It is marketed under the name Femara.
The U.S. label on the drug already warns that it has been associated with birth defects, but uneasiness arose when a researcher in Canada published a report noting cases where the drug had been given to pregnant women.
The drug “should not be used in women who may become pregnant, during pregnancy and/or while breast-feeding, because there is a potential risk of harm to the mother and the fetus, including risk of fetal malformations,”

What is your point exactly?

That you want the drug withdrawn altogether?

The warnings on the packaginhg are not clear enough, or the same in all countries?

Or that Doctors are misprescribing the drug and the manufacturer should invest more in educating the doctors that will prescribe tghe drug.

Can you also cite the specific journals that you referenced to make you initial point?

frasermoss said:

What is your point exactly? my exact point is that the said drug has been misused by many doctors ....they earn by under table methods... The warnings on the packaginhg are not clear enough, or the same in all countries? Warnings are clear .it was observed in many research labs that the drug causes many inborn errors. Or that Doctors are misprescribing the drug and the manufacturer should invest more in educating the doctors that will prescribe tghe drug. Doctors are at fault... Can you also cite the specific journals that you referenced to make you initial point?

MADE A GOOD AND OPEN STUDY OF THE BELOW ARTICLE...IT A PASTE COPY OF A LEADING HEALTH MAGAZINE "NO NEED TO DISCLOSE THE NAME"



Novartis warns about unapproved use of breast cancer drug as fertility treatment

WASHINGTON - The manufacturer of the breast cancer drug letrozole is warning fertility doctors that it has been associated with birth defects and should not be used to help women become pregnant.

Letrozole is approved for use only in postmenopausal women with breast cancer. Nevertheless, Swiss drug manufacturer Novartis cited evidence that some doctors have prescribed it as a fertility treatment because it suppresses estrogen and can promote ovulation. It is marketed under the name Femara.

Novartis is sending letters to fertility doctors worldwide to reiterate a warning that the drug should not be given to women who may be pregnant, spokeswoman Kim Fox said Tuesday.

The U.S. label on the drug already warns that it has been associated with birth defects, but uneasiness arose when a researcher in Canada published a report noting cases where the drug had been given to pregnant women.

After the report, Novartis reviewed its safety database and found 13 reports of pregnant women receiving the drug worldwide, contrary to its warning label.

Of those 13, at least two had miscarriages and two had children with birth defects, Fox said. It was not clear how many of these women were given the drug to increase their fertility as opposed to some other reason.

Health Canada, the countrys health care agency, issued the warning jointly with Novartis to fertility specialists, gynecologists and obstetricians.

In its letter in Canada, Novartis said it is aware that Femara is being used to stimulate ovulation in women who are infertile, or unable to become pregnant, as a treatment to increase their chances of becoming pregnant.

The drug should not be used in women who may become pregnant, during pregnancy and/or while breast-feeding, because there is a potential risk of harm to the mother and the fetus, including risk of fetal malformations, the company said.

The U.S. Food and Drug Administration has taken no action, but a spokeswoman said the agency was reviewing the matter. Novartis plans to send a letter to U.S. fertility specialists by the end of the week, Fox said.

It is unknown how many women have been prescribed the drug as a fertility treatment. Doctors in many specialties sometimes prescribe drugs for uses not approved by health regulators, believing the drug can still serve to treat a condition.

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