Researchers in Rome recently correlated an increase in circulating Nerve Growth Factor (NGF) with the early stages of passionate love. They found a significant increase in NGF in people who described themselves as passionately in love compared to people who were single or in long term relationships. Levels of NGF fell off after about one year.

I think this is evidence that falling in love makes you brain damaged, and it takes about a year for your body to repair your neurons and bring you back to your senses!!

Raised plasma nerve growth factor levels associated with early-stage romantic love
Psychoneuroendocrinology, In Press, Corrected Proof, Available online 10 November 2005,
Enzo Emanuele, Pierluigi Politi, Marika Bianchi, Piercarlo Minoretti, Marco Bertona and Diego Geroldi

SanDiablo said:

I think this is evidence that falling in love makes you brain damaged, and it takes about a year for your body to repair your neurons and bring you back to your senses!!

LOL!

So now is the time to experiment, whether elevating NGF levels makes people fall in love (or remain in love).

Are there medicines (or other materials) which cause elevetion of NGF levels? (where can I get retinoic acid?)
I'd like to try and recreate my wife & mine's initial love :-)

What cell types does NGF affect?

do you remember the Ignobel winner for the serotonin uptake in platelets of romantic lovers? be careful...
;)

I just wrote this, about this subject.

Nerve Growth Factor and early stage romantic love, DHEA and Testosterone



Copyright 2005, James Michael Howard, Fayetteville, Arkansas, U.S.A.



Based on the new finding that nerve growth factor increases in "early stage romantic love" then dissipates within a year (Psychoneuroendocrinology 2005; Emanuele, et al.), I suggest the following:

"When we experience things new, we produce a stress response. This produces the DHEA to cortisol ratio. If the experience produces more DHEA than cortisol, this produces "good" responses; if cortisol is too high, this is a "bad" response.

DHEA increases nerve growth factor; cortisol reduces it. One falls in love with another who increases their DHEA to cortisol response. As the "newness" dissipates, the effects of growth caused by DHEA and NGF also dissipates. If the original, and subsequent, effects are strong enough, a "bond" is formed by growth caused by DHEA and NGF."

Testosterone is paramount in early stage romantic love. Testosterone has been demonstrated to be involved in male facial attractiveness and coitus activity in women (see articles at www.anthropogeny.com/evolution.html ). Testosterone reduces DHEA levels but also increases nerve growth factor. That is, increased testosterone probably increases the NGF response to early stage romantic love, but also may cause a more rapid decline in the stress response elicited by male and female interactions. Therefore, this explanation may also explain why men stray faster than women. However, my work also suggests that the "secular trend," the increase in size and earlier puberty of children, is caused by an increase in the percentage of individuals of higher testosterone with time within the population. This is primarily driven by women of higher testosterone. Therefore, women are becoming more and more like men and this will shorten the time between "early stage romantic love"s stimulation of NGF and its dissipation in men and women.