In Vivo PK [View Printable]
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Merryl
Group: Member
Posts: 6
Joined: Oct 26, 2004
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Does anyone have any tips on running PK more efficiently? |
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 Posted Nov 03, 2004, 0:21 AM |
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Soudabeh
Group: Member
Posts: 257
Joined: Apr 23, 2004
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| Merryl said: | | Does anyone have any tips on running PK more efficiently? |
Could you please provide a more detailed question? |
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| Posted Dec 24, 2004, 0:09 AM |
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Merryl
Group: Member
Posts: 6
Joined: Oct 26, 2004
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| Soudabeh said: | | Merryl said: | | Does anyone have any tips on running PK more efficiently? |
Could you please provide a more detailed question? |
Does anyone have any tips or tricks relating to the more efficient running of in vivo pharmacokinetics? I am interested in increasing my N while not unduly increasing my workload. I would like to be more efficient and therefore more productive with PK in rats and mice. |
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| Posted Jan 07, 2005, 0:15 AM |
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kazey
Group: Member
Posts: 4
Joined: Feb 21, 2007
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| Merryl said: | | Soudabeh said: | | Merryl said: | | Does anyone have any tips on running PK more efficiently? |
Could you please provide a more detailed question? |
Does anyone have any tips or tricks relating to the more efficient running of in vivo pharmacokinetics? I am interested in increasing my N while not unduly increasing my workload. I would like to be more efficient and therefore more productive with PK in rats and mice. |
I would suggest using an autosampler with your LC/MS/MS - it is an easy and obvious way to increase your throughput :)). |
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| Posted Feb 21, 2007, 12:59 PM |
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ramesh padodara
Group: Member
Posts: 22
Joined: Jul 19, 2008
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you may first try with in-vitro (liver microsomal0 studies and then do in-vivo. While in-vivo screening use only 4-6 animal per compound and analysed it LCMS/UPLC. This insrument could consume less time than other method of analysis. |
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R J Padodara
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| Posted Jul 29, 2008, 23:57 PM |
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leining77
Group: Member
Posts: 1
Joined: Nov 16, 2008
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Actually, most of the in vitro data were very differ from the in vivo, using 4-6 rats to find the pilot PK is more accurately, based on my experience. And it's not expensive than in vitro screen. |
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| Posted Nov 16, 2008, 21:28 PM |
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