A muscarinic alkaloid ,pilocarpine is obtained from the leaves of tropical American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at the muscarinic acetylcholine receptor M3 due to its topical application, e.g., in glaucoma and xerostomia. It has been used in the treatment of chronic open-angle glaucoma and acute angle-closure glaucoma for over 100 years, and is often used as an antidote for Scopolamine, Atropine and Hyoscyamine poisoning. It is also used to treat dry mouth (xerostomia), stimulate sweat glands in a sweat test to measure the concentration of chloride and sodium that is excreted in sweat, and diagnose cystic fibrosis (CF). Another, it is used to induce chronic epilepsy in rodents, commonly rats, and has been known to cause excessive sweating, bronchospasm, excessive salivation, increased bronchial mucus secretion, hypertension, tachycardia, browache and diarrhea.