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H5N1 strain of avian virus

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Sandy

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I have been reading about the H5N1 strain of avian flu virus. I learned that humans have no immunity to this strain. What kind of precautions we should take? how this virus will evolve into the virulent stage of a pandemic. Does cooking kill the virus and is it spread only by touching the raw meat? is it airborne? what about the eggs, are they infected with the virus as well?

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Posted Sep 26, 2005, 3:25 AM
roudi

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Sandy said:
I have been reading about the H5N1 strain of avian flu virus. I learned that humans have no immunity to this strain. What kind of precautions we should take? how this virus will evolve into the virulent stage of a pandemic. Does cooking kill the virus and is it spread only by touching the raw meat? is it airborne? what about the eggs, are they infected with the virus as well?


I learned that H5N1 is heat sensitive and can be destroyed when exposed to only 51C centigrade temperature. Any input?

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Posted Oct 17, 2005, 20:54 PM
SanDiablo

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Frequent hand washing is the best prevention of illness. Like the 'regular' flu, it is spread through contact of mucus secretions (snot, spit and sh...feces). You will not get bird flu from eating infected meat.

The worry is H5n1 will recombine with a human flu virus in a doubly infected person or pig and create trouble. So get a regular flu shot - it may not protect against Bird Flu, but it will keep you healthier over all, and you won't be the source of the "new" virus!

From the CDC website:

HONG KONG (AFP) - Following is an updated factfile on scientific and medical aspects of bird flu:


WHAT IS BIRD FLU? Bird flu is also called avian influenza. There 15 strains of flu that affect birds, but the one causing the amplifying global scare is the H5N1 subtype. It has circulated in migrating wild birds for years and has spread to poultry flocks, starting in Southeast Asia, spreading to Russia and now reaching Turkey. It is highly lethal to domesticated birds.

HOW IT SPREADS TO HUMANS: Avian flu was first identified in Italy around a century ago. It was not thought to be transmissible to humans until 1997, when the first human cases were seen in Hong Kong, also involving H5N1. In the latest outbreak, around 60 people in Asia have died, amounting to roughly half the known number of infections, which is a very high fatality rate. Almost all these casualties were directly exposed to infected fowl, making contact with the virus through the birds' saliva, nasal secretions and faeces, which become dry, pulverised and are then inhaled. Avian flu is not a food-borne virus, so the risk from eating properly-cooked chicken is negligible.

SYMPTOMS: Bird flu in humans causes symptoms that are like human flu, such as fever, cough, sore throat and muscle aches, conjunctivitis, pneumonia and other severe respiratory diseases.

THE RISK: At present, H5N1 is not easily transmitted from bird to human. In other words, a person would have to pick up a lot of virus in order to be infected. Nor is it easily passed from human to human: there have been only three suspected cases, in Thailand, Hong Kong and Vietnam, where this is believed to have happened. The big worry, though, is that H5N1 could pick up genes from conventional human flu viruses, making it both highly lethal and highly infectious. Because it would be a radically new pathogen, no one would have any immunity to it. The mutation could occur if H5N1 co-infects a human who already has ordinary flu or the agent is picked up from poultry by an animal such as a pig that can carry bird and regular flu strains.

PAST PANDEMICS: In the 20th century, there have been three flu pandemics, in 1918-19, 1957-58 and 1968-69. The worst of all was the 1918-19 pandemic, which slew as many as 50 million people -- more than the death toll from AIDS in more than two decades. The latest research suggests that the so-called Spanish flu virus was itself a bird flu virus that leapt the species barrier to humans. The World Health Organisation (WHO) says the next pandemic is simply a matter of time. Jet travel and the world's huge population today mean the toll from Spanish flu could be easily surpassed.

VETERINARY CONTROLS: These are the time-honoured first line of defence in any outbreak of animal disease. The task is to identify farms where there is an outbreak of H5N1, quarantine the area, kill all fowl suspected to be in contact with it, disinfect machinery, vehicles and clothing, and bar sales of poultry products from the affected region. But these controls are only really dependable if a country has a good surveillance network and responds quickly and effectively to an outbreak. One vital tool is compensation: without some reimbursement, farmers may be loth to report flu among their flock and be tempted to sell on diseased birds, thus amplifying the epidemic.

HUMAN PREPAREDNESS: Countries are being urged to stockpile antiviral drugs, beef up surveillance and response systems and prepare for the swift manufacture and distribution of an effective vaccine, for when it becomes available. Some authorities are encouraging vaccination against conventional flu strains for people who could be exposed to bird flu, in order to discourage the risk of co-infection. On the international front, the WHO is striving to improve the sharing of information and virus samples -- vital in the search for vaccines and treatment -- and is coordinating closely with other agencies responsible for food safety and animal health.

VACCINE: No definitive vaccine against the viral threat is available, because no one knows the precise shape that it will take after mutating to the feared highly contagious form. Several prototypes are being explored, but the risk is that they could be only partially effective or even useless because the virus' genetic shape will have changed and will not be recognised by antibodies. If a pandemic does occur, one worry is about manufacturing capacity and distribution: making enough of the vaccine and getting it on time and to the right people, without causing panic or a black market or leaving poor countries helpless.

DRUGS: The range of antiviral drugs is small, but especially so when it comes to bird flu. Four antiviral medications are commonly prescribed for the A category of influenza viruses of which H5N1 is a subgroup. Two of them, amantadine and rimantadine, are ineffective against H5N1. The other two are zanamavir (commercialised as Relenza) and the widely-stockpiled oseltamivir, commercialised as Tamiflu. These medications are called neuraminidase inhibitors, which block the virus from replicating. If taken within a couple of days of the onset of illness, they can ease the severity of some symptoms and reduce the duration of sickness. According to the US Centers for Disease Control and Prevention ( CDC), the two drugs "would probably work" against H5N1 infection, but more work is needed to confirm this.

Sources: WHO, CDC, US National Institute of Health and Infectious Diseases (NIAID), World Organisation for Animal Health (OIE).

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A group of frogs is called an army.
A group of army officers is called a mess.

Posted Oct 20, 2005, 21:19 PM
parvoman

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There were reports that the CDC had isolated / resurected the virus that caused the 1918-19 pandemic. Does anyone know whether that virus was found to be related to H5N1. If H5N1 was the flu strain that mutated then, then it may be possible to develop a vaccine that is at least partially effective against future mutants. But clearly scaling up production would be very difficult given the biohazard level (probably 4) of the resurected flu virus.

Maybe we can get Dustin Hoffman to suit-up and repeat his trick of generating enough anti-serum to treat a small town from an ape the size of my cat!

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Posted Oct 21, 2005, 16:32 PM
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