I've been hearing about "accommodation" in organ transplants where humoral responses do not cause damage to graft, even in some ABO-incompatible cases. Could someone help me understand more about this? Possible mechanisms?

ozawa said:

I've been hearing about "accommodation" in organ transplants where humoral responses do not cause damage to graft, even in some ABO-incompatible cases. Could someone help me understand more about this? Possible mechanisms?

Although various agents and regimens have been developed to control immune responses, the difficulty of achieving control of immune responses to xenografts has stimulated interest in the application of tolerance or accomodation(resistance to immune-mediated injury) for improving survival. Sometimes several years after transplantation the humoral rejection ceases to occur after the accomodation has been established. Putative mechanisms of such tolerance has been debated by researchers, which one is the most acceptable?