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Why work with GPCRs? [View Printable]
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MariaK
Group: Member
Posts: 1
Joined: Aug 02, 2005
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I was wondering why some of you have chosen wo work with GPCRs? I am asking because i am trying to decide between two research projects and would like some advice from people who already work on them...specifically my project would be on rhodopsin.
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 Posted Aug 02, 2005, 8:02 AM |
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DD
Group: Member
Posts: 64
Joined: Dec 17, 2004
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| MariaK said: | I was wondering why some of you have chosen wo work with GPCRs? I am asking because i am trying to decide between two research projects and would like some advice from people who already work on them...specifically my project would be on rhodopsin.
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GPCR(G protein Coupled Receptor) with 7 transmembrane domains, are one of the largest super family of proteins and a major class of targets for drug discovery. They play a remarkable role in a large number of physiological conditions of the body such as: smell, taste, vision, neurotransmission, hormone secretion, chemotaxis, exocytosis, embryogenesis, cell growth/ differentiation, viral infection and carcinogenesis. |
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| Posted Aug 03, 2005, 13:39 PM |
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blader
Group: Member
Posts: 2
Joined: Jan 26, 2006
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You forgot to mention that GPCR's are the largest known gene family |
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| Posted Jan 27, 2006, 0:02 AM |
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pchang
Group: Member
Posts: 4
Joined: Jun 07, 2006
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In addition to all the mentioned biological processes that GPCRs mediate, they are very successful pharmaceutical targets. Depending on whom you talk to, GPCRs and their downstream signaling genes compose upto 40-50% of modern therapeutic targets! |
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| Posted Jun 07, 2006, 21:25 PM |
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