do you know any scientific investigatement about Noni Fruit Juice and its effects on Immune system and decreasing cancer and tumor cells???

Eur J Gastroenterol Hepatol. 2005 Apr;17(4):445-7.
Millonig G, Stadlmann S, Vogel W.
Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia).


Hawaii Med J. 2004 Jun;63(6):182-4.
Are immune responses pivotal to cancer patient's long term survival? Two clinical case-study reports on the effects of Morinda citrifolia (Noni).
Wong DK.

Angiogenesis. 2003;6(2):143-9.
Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni).
Hornick CA, Myers A, Sadowska-Krowicka H, Anthony CT, Woltering EA.

Phytother Res. 2003 Dec;17(10):1158-64.
Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice.
Furusawa E, Hirazumi A, Story S, Jensen J.

Integr Cancer Ther. 2002 Jun;1(2):110-20; discussion 120.
From Polynesian healers to health food stores: changing perspectives of Morinda citrifolia (Rubiaceae).
McClatchey W.

Ann N Y Acad Sci. 2001 Dec;952:161-8.
Cancer preventive effect of Morinda citrifolia (Noni).
Wang MY, Su C.

Cancer Res. 2001 Aug 1;61(15):5749-56.
Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line.
Liu G, Bode A, Ma WY, Sang S, Ho CT, Dong Z.

Am J Kidney Dis. 2000 Feb;35(2):310-2.
Noni juice (Morinda citrifolia): hidden potential for hyperkalemia?
Mueller BA, Scott MK, Sowinski KM, Prag KA.


Phytother Res. 1999 Aug;13(5):380-7.
An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity.
Hirazumi A, Furusawa E.

Proc West Pharmacol Soc. 1996;39:7-9.
Immunomodulation contributes to the anticancer activity of morinda citrifolia (noni) fruit juice.
Hirazumi A, Furusawa E, Chou SC, Hokama Y.

A. Hirazumi, E. Furrasawa, S.C. Chou & Y. Hokama. "AntiCancer Activity of Morinda Citrifolia on Intraperitoneally implanted Lewis Lung Carcinoma in Syngenic Mice." Proc West Pharmacol Soc. 37: 145-146 (1994).

T. Hiramatsu, M. Imoto, T. Koyano, K. Umezawa. "Induction of Normal Phenotypes in RAS-transformed cells by Damnacanthal from Morinda Citrifolia." Cancer Letters 73 (1993) 161-166.

C. Younos, A. Rolland, J. Fluerentin, M. Lanhers, R. Misslin, F. Mortier. "Analgesic and Behavioral Effects of Morinda Citrifolia." Planta Medica 56 (1990). 430-434.

http://www.tipsofallsorts.com/noni0.html

Beware - there is much stuff out there, espcially on the internet, focusing only on the "positive" data thanks to those trying to market the product.

Thank you for your interest...
As i see on your investigation and on my investigations generally, results are positive.
But i wanna learn that if any negative result possibility for long time usage on healthy people, who just wanna boost their immune system, etc...

well if you read the first refernce in the list it is a case report of somoene suffering from acute hepatitis after taking too much NONI.

A 45-year-old patient was sent to our department because of highly elevated transaminases and elevated lactate dehydrogenase. His medical history was unremarkable and he took no medication on regular basis. Physical examination did not detect any abnormalities. There was no evidence for viral hepatitis, Epstein-Barr virus or cytomegalovirus, autoimmune hepatitis, Budd-Chiari syndrome, haemochromatosis or Wilson's disease. During the interview he admitted that for 'prophylactic reasons' he had been drinking the juice of Noni (Morinda citrifolia), a Polynesian herbal remedy made from a tropical fruit, during the preceding 3 weeks. This gave rise to the suspicion of herbal toxicity, which was confirmed by a liver biopsy. After ceasing the ingestion of Noni, transaminase levels normalized quickly and were within normal ranges 1 month after the first presentation. To our knowledge, this is the first report of hepatotoxicity caused by this herbal remedy, which has been highly praised in the tabloid press.

do you know any scientific investigatement about Noni root? can u give to me the journal or any information regarding to the compounds inside the root of morinda citrifolia as a guideline for me to do the research....tq

nhs_kantan said:

do you know any scientific investigatement about Noni root? can u give to me the journal or any information regarding to the compounds inside the root of morinda citrifolia as a guideline for me to do the research....tq

Did you see the post I made on this 2 posts before yours?
there are lots of journal references there

Here is a link to a referenced monograph on Noni which gives a fairly balanced view of the evidence of Noni's effectiveness and includes info on active constituents http://www.healthnotes.info/http/gclcatalog/getContent.cfm?catid=13&startrow=1&org=DSEA&ContentID=2136001

Here are the references used within the link from tbc's previous post which focus on the active constituent of noni appear to be polysaccharides and a compound known as damnacanthal.

1. Levand O, Larson HO. Some chemical constituents of Morinda citrifolia. Planta Med 1979;36:1867.

2. Hirazumi A, Furusawa E. An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity. Phytother Res 1999;13:3807.

3. Hiramatsu T, Imoto M, Koyano T, Umezawa K. Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia. Cancer Lett 1993;73:1616.




... and here are the references which demonstrate immune enhancing or sedative effects.


4. Hirazumi A, Furusawa E, Chou SC, Hokama Y. Anticancer activity of Morinda citrifolia (noni) on intraperitoneally implanted Lewis lung carcinoma in syngeneic mice. Proc West Pharmacol Soc 1994;37:1456.

5. Hirazumi A, Furusawa E, Chou SC, Hokama Y. Immunomodulation contributes to the anticancer activity of morinda citrifolia (noni) fruit juice. Proc West Pharmacol Soc 1996;39:79 .

6. Younos C, Rolland A, Fleurentin J, et al. Analgesic and behavioural effects of Morinda citrifolia. Planta Med 1990;56:4304.