Stix said:

Is there a fundamental difference between something forming heterodimers (e.g. two different GPCR or EGFR with PDGFR) and finding GPCR in a complex with a Tetraspanin (CDmolecule)? Since PDGFR can be found in a complex with a GPCR and c-Src, would it be invalid to say that the GPCR heterodimerizes with PDGFR? If so, does the functional association of these two receptors at least imply that there could be heterodimerization taking place?

I have read that in contrast to other cell surface receptors like tyrosine kinase receptors, for which dimerization is mandatory for activation process, G-protein Coupled Receptors were thought until recently- to function as monomeric units. However, recent findings have shown that GPCRs could exist and be activated as oligomeric complexes. This can show that heterodimerization could be also possible. Does anybody working on this subject and has some results to share?